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2+ hour, 30+ min ago  (470+ words) In their landmark 1961 paper of the lac operon, Nobel laureates Fran'ois Jacob and Jacques Monod speculated that RNA might control gene activity in bacteria through base-pairing interactions. But once protein transcription factors were discovered, the idea was tossed aside. Sixty…...

10+ hour, 12+ min ago  (376+ words) Why validate after protein purification When combined with the Amersham" ImageQuant" 800 Western blot imaging system and ImageQuant" TL analysis software, researchers can quickly perform quantitative densitometry to determine whether the purification was satisfactory or whether further optimization is needed. This…...

5+ hour, 18+ min ago  (1130+ words) Summary: For the first time, researchers have captured the molecular "dance" of TRPM8, the protein in our nerve cells responsible for sensing cold and the cooling tingle of menthol. The study uses a combination of flash-freezing (cryo-EM) and real-time motion tracking…...

5+ hour, 20+ min ago  (715+ words) UCSF researchers capture the first atomic-level snapshots of the cold-sensing protein in action. image:A three-dimensional reconstruction of TRPM8 embedded in a cell membrane. Four TRPM8 proteins are assembled as a functional ion channel. The TRPM8 proteins are shown in light blue and…...

6+ hour, 5+ min ago  (748+ words) When you reach into a bucket of ice, step outside on a snowy day, or feel the tingle of menthol toothpaste, a protein in your nerve cells called TRPM8 springs into action, opening like a tiny gate to send a "cold…...

4+ hour, 58+ min ago  (389+ words) Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na'Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) " Seminar: The Rare Microbiome, Contamination and Planetary Protection Pushing back the detection limits,…...

5+ hour, 2+ min ago  (304+ words) Every plant cell is the product of a biological merger billions of years ago. Chloroplasts are key structures in plants and algae that capture sunlight, but originally they were free-living bacteria that took up residence inside another cell. Over time,…...

1+ day, 6+ hour ago  (600+ words) March 24 (Reuters) - Revealing the "limitations of cloning, researchers who repeatedly cloned mice for two decades have discovered that such serial duplication triggers grave genetic mutations that accumulate over the generations and ultimately become fatal. The research contradicted the notion that…...

1+ day, 8+ hour ago  (215+ words) This latest technique is called Seq-Scope-eXpanded, or Seq-Scope-X. It enables scientists to visualize the barriers between cells and the genetic transcripts they contain, even when they are in different parts of the cell, such as the cytoplasm or nucleus. "We…...

1+ day, 9+ hour ago  (206+ words) Mysore/Mysuru: Dr. S. Shankara Bhat, Plant Pathologist and former Professor of Botany and Microbiology Department, University of Mysore (UoM), was conferred the prestigious FPSI (Fellow of Indian Phytopathological Society-2024) Fellowship in recognition of his lifelong contributions to Plant Health Management....