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18+ hour, 50+ min ago   (354+ words) To assess whether LetA is evolutionarily related to known transporter families, we performed a structure-based search of the Protein Data Bank (PDB) using Foldseek37. We were unable to identify structural similarity to known transporter folds, suggesting that LetA represents a new…...

19+ hour, 50+ min ago   (1418+ words) Sidewinder can also assemble defined diversities across a large number of positions along the entire length of a DNA sequence to construct combinatorial libraries. In a combinatorial library, each variable position is diversified and assembled into a synthetic sequence with…...

20+ hour, 50+ min ago   (85+ words) Vertebrate vision is mainly accommodated by a pair of lateral image-forming camera-type eyes and is supplemented in non-mammalian vertebrates by a dorsal pineal complex (pineal and parapineal organs) functioning as photoreceptive and/or endocrine organs1. The pineal complex shares a common…...

21+ hour, 56+ min ago   (301+ words) Cereblon (CRBN) is the target of thalidomide derivatives1 that achieve therapeutic efficacy against some haematologic neoplasias2,3,4 by recruiting neosubstrates for degradation5,6,7. Despite the intense investigation of orthosteric thalidomide derivatives, little is known about alternate binding sites on CRBN. Here we report an evolutionarily…...

1+ day, 3+ hour ago   (712+ words) Creutzfeldt-Jakob disease, Gerstmann-Str'ussler-Scheinker disease, fatal insomnia, Kuru disease, and mad cow disease are all neurodegenerative diseases that have a common cause: prions. Although they are rare conditions, a diagnosis guarantees death within a year due to the nature of the…...

1+ day, 10+ hour ago   (293+ words) Hendrix Genetics aims to become the number one or two in every animal species with which it is active. The recent acquisition of Danish Genetics underscores that ambition. Capital is available for acquisitions. About 15% of the world's pork is produced…...

1+ day, 13+ hour ago   (438+ words) CBSE Class 10 Science [Biology] 2026: Life Processes Simplified CBSE Class 10 Biology Life Processes is a high-weightage chapter for students appearing in the 2026 board examinations. This section is meant for Class 10 students and parents, offering an exam-focused overview aligned with current CBSE…...

2+ day, 33+ min ago   (882+ words) In a remarkable investigation molding the future of genetic research in domestic animals, a comprehensive study uncovers critical insights into the population structure, regions of homozygosity (ROH), and selection signals of two distinct breeds of domestic goats. The research, spearheaded…...

2+ day, 3+ hour ago   (1005+ words) Recent advancements in molecular biology have illuminated the complex and often underestimated world of noncoding RNAs (ncRNAs) and their pivotal role in skeletal muscle development. Traditionally viewed as mere regulatory entities with no coding capacity, ncRNAs have become the focus…...

2+ day, 7+ hour ago   (696+ words) In a groundbreaking advance poised to reshape the therapeutic landscape of oral squamous cell carcinoma (OSCC), recent research spearheaded by Wang X. has illuminated a compelling synergy between astragalus polysaccharide (APS) and STM2457, a novel m6A RNA methylation inhibitor. As OSCC remains a…...