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A meta-analysis of 8,461 Native Hawaiians and Samoans identified 25 significant genetic associations across 13 cardiometabolic traits, including a strengthened link between a CREBRF variant and fasting glucose. A meta-analysis of more than 8,000 Native Hawaiians and Samoans identified 25 genome-wide significant genetic associations across…
Experiments in amoebae and murine microglial cells show that EsxA initiates repairable vacuole membrane lesions, while PDIM helps those lesions progress toward rupture and cytosolic escape. Subject of Research: Distinct roles of EsxA and PDIM in mycobacterial vacuole membrane damage…
AllSci Stanford University researchers developed a programmable RNA base-editing system built from human proteins that outperformed established CRISPR-based editors in laboratory comparisons, potentially offering a less immunogenic approach to therapeutic RNA modification. The platform, described in Nature Biotechnology, repurposes the…
Single-nucleotide mutation maps and simulations indicate that mutation bias and GC-biased gene conversion largely shape nucleotide composition near human transcription start sites. A single-nucleotide analysis of human genetic variation found a pronounced hypermutation peak at transcription start sites (TSSs) of…
The hantavirus outbreak aboard a cruise ship sickened passengers and claimed lives, reminding the world that these rare but deadly viruses remain a serious public health threat. While hantavirus infections are uncommon, severe cases can be fatal and there are…
An in vitro study found that five plant compounds impaired efflux-pump activity and reduced P. aeruginosa PAO1 biofilm formation, with salvianolic acid A producing the strongest effects. Gene-expression analysis supplied an additional level of evidence. Following treatment with salvianolic acid A, qRT-PCR…
An approximately year-long monitoring study found that 365- and 395-nanometre UV-A photographs identified 303 olms from nine Italian caves using stable, naturally occurring skin patterns rather than artificial tags.
Researchers have identified a previously undescribed lineage of Asian horned toad from the Yarlung Tsangpo Grand Canyon in Xizang, China. The discovery is based on three adult female frogs collected at Beibeng Township, Motuo County, Nyingchi City, in May 2025. The…
A Science Bulletin review finds that super-resolution microscopy is shifting from sharper visualization toward validated measurements of molecular organization and dynamics in living systems. Super-resolution microscopy is moving beyond the production of sharper images toward a more demanding goal: making…
They ultimately distinguished 376 consensus OTUs, 137 of which contained lichen-derived sequences. Among those, 23 contained Arthoniales sequences, with 21 newly detected in the study and two taken from earlier GenBank records from Enterographa pallidella and Opegrapha vulgata. Six consensus groups remained paraphyletic. Some…