4+ day, 14+ hour ago   (377+ words) The cohesin complex is widely known for forming chromatin loops and contributing to genome organization. In this study, the researchers asked whether cohesin also controls the physical properties of euchromatic domains at the level of individual nucleosomes. To address this,…...

1+ week, 2+ day ago   (157+ words) Leonardo Riella, MD, PhD, lead author, Center for Transplantation Sciences and the Division of Nephrology, Mass General Brigham After approximately six months, immunosuppression was reduced in the setting of infection. The xenotransplant subsequently developed microvascular injury and inflammation that progressed…...

1+ week, 2+ day ago   (260+ words) A study in budding yeast suggests that changes in membrane lipids trigger a braking system that slows internal protein transport when the endoplasmic reticulum comes under stress, comparable to modern logistics networks where shipments are slowed when distribution hubs are…...

1+ week, 5+ day ago   (151+ words) Cell biology sits at the heart of understanding how living systems function, change, and respond to disease. From preserving valuable cell samples to investigating aging, immunity, cancer, and cellular behavior, advances in the field are giving researchers new ways to…...

2+ week, 1+ day ago   (597+ words) Craniosynostosis is a congenital developmental disorder in which the skull's cranial sutures fuse prematurely. Researchers uncover molecular pathway driving craniosynostosis Craniosynostosis is a congenital developmental disorder in which the skull's cranial sutures fuse prematurely. Although genetic mutations can drive the…...

2+ week, 1+ day ago   (106+ words) LMU researchers identify a molecular mechanism that enables single-celled parasites to switch on the machinery they need to move and invade host cells. What surprised us is that methylation is not acting here in the nucleus, where it is best…...

2+ week, 4+ day ago   (246+ words) Researchers have developed a "scaffold" that mimics natural tissue and could lead to more durable rotator cuff repairs, including for large injuries and cases involving bone and tissue degeneration that are often the most difficult to fix. Devised by a…...

3+ week, 3+ day ago   (451+ words) At a modest scale, dome‑based patient‑derived organoid (PDO) culture often requires tens of hours of manual work each week. Since manual culture workflows rely significantly on operator skill, they introduce variability and push routine tasks into evenings and…...