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News
Chemists Craft a One-Handed Molecule That Disarms a Cell-Death Protein
16+ hour, 1+ min ago (661+ words) A single protein called BAX sits at the gateway between life and death for human cells. When tissues are injured, stressed, or deprived of oxygen, BAX springs into action, punching holes in the outer membrane of mitochondria and triggering the…...
BenchHub Turns Computational Biology Benchmarking Into a Living,
17+ hour, 16+ min ago (618+ words) Every day, computational biologists release new methods for analyzing genomes, single cells, microbiomes and molecular signatures, and every day researchers struggle with the same question: which method actually works best for their data? The answer usually depends on benchmarks—structured…...
Transposable Elements Drive the Birth of Vast Satellite DNA Repertoires in
18+ hour, 41+ min ago (597+ words) The genomes of true frogs have long puzzled geneticists. Amphibians are famous for carrying some of the largest and most repetitive genomes among vertebrates, and yet the detailed architecture of their repetitive DNA has remained poorly explored compared with mammals,…...
DartUniFrac Brings Megascale Computing to Microbiome Diversity Analysis
21+ hour, 7+ min ago (512+ words) Researchers have introduced DartUniFrac, a new software tool designed to carry out UniFrac-based microbiome comparisons at a scale that was previously impractical....
New Rust Toolkit Supercharges Sex Determination Studies in Non-Model
21+ hour, 27+ min ago (628+ words) A new open-source software package promises to transform how biologists hunt for the genetic switches that separate males from females in species with no reference genome....
Heart cells can ‘remember’ stress and use it for protection during chemotherapy
1+ day, 1+ hour ago (1157+ words) Early stress in mitochondria before birth helped mouse hearts resist later chemotherapy damage by creating lasting protective changes. Chemotherapy can save lives, but some drugs can also put the heart under serious strain. Doxorubicin, a chemotherapy used against several cancers,…...
Hidden RNA Switch Helps Esophageal Cancer Evade Ferroptotic Cell Death
1+ day, 2+ min ago (73+ words) Esophageal cancer remains one of the most lethal malignancies worldwide, and a new study published in Cellular and Molecular Life Sciences has uncovered a previously hidden molecular mechanism that helps these tumors survive. Researchers led by Yi Zhang, Tao Yan,…...
Dark DNA’s Long RNAs Emerge as Master Regulators of Colorectal Cancer
1+ day, 1+ hour ago (90+ words) For decades, the vast stretches of the human genome that do not encode proteins were dismissed as evolutionary baggage, a biological wasteland dismissed with the shorthand of “junk DNA.” A comprehensive new review published in Nature Reviews Gastroenterology & Hepatology makes…...
Newly Discovered Trypsinogen Variants Drive Immune Responses in
1+ day, 2+ hour ago (654+ words) A team of researchers in China has uncovered a genetic clue that may help explain why some patients develop immunoglobulin G4-related disease, a chronic fibroinflammatory condition that can strike the pancreas, salivary glands, and other organs....
Cohesin Builds Molecular Fences That Keep Active Genome Domains From Mixing
1+ day, 3+ hour ago (83+ words) Inside the nucleus of every human cell, roughly two meters of DNA are packed into a space only a few micrometers across, and how that packing is organized has profound consequences for health and disease. A new study published in…...