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News
Chromosomal Chaos in Tumors May Blind the Immune System, Genome Study Finds
26+ min ago (758+ words) Scientists in Japan have taken one of the most detailed looks yet at how large-scale genome disruption inside tumor cells may quietly rewire the immune landscape around them, and their findings could help explain why some cancers mount virtually no…...
Miniature Pig Heart Atlas Reveals a Unique Lipid-Burning Cardiomyocyte
36+ min ago (542+ words) The Wuzhishan miniature pig has long been considered one of the most promising large-animal models for cardiac research and xenotransplantation, prized for its physiological closeness to humans and its manageable size. Yet despite its growing importance in translational medicine, no…...
AI Graph Tool scFormer Uncovers Rare Cell States Hidden in Single-Cell and
1+ hour, 52+ min ago (75+ words) Rare cells punch far above their weight in biology. Populations that make up less than one percent of a tissue can drive tumor progression, immune evasion, drug resistance, and relapse, while others mark the first steps of lineage commitment or…...
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
2+ hour, 6+ min ago (55+ words) The innate immune system is built on a paradox: the same molecular machinery that defends the body against infection can, when mishandled, turn that defense against the body itself. Few proteins embody this tension as vividly as NLRP6, a human pattern-recognition…...
Scientists Combine Genome and Gene Expression Data to Pinpoint Genes That
2+ hour, 43+ min ago (580+ words) Plant height may seem like a simple trait, but in soybean it sits at the heart of one of agriculture’s most consequential trade-offs. Tall plants can shade weeds and capture light, yet they topple in wind and rain, complicate harvest,…...
Immune Enzymes From Neutrophils Quietly Switch Off Fat Burning
2+ hour, 56+ min ago (634+ words) For years, immunologists have regarded neutrophils as short-lived first responders, cells that surge into infected or injured tissue, unleash a burst of antimicrobial chemicals, and then die within hours....
DartUniFrac Brings Megascale Computing to Microbiome Diversity Analysis
3+ hour, 45+ min ago (512+ words) Researchers have introduced DartUniFrac, a new software tool designed to carry out UniFrac-based microbiome comparisons at a scale that was previously impractical....
Heart cells can ‘remember’ stress and use it for protection during chemotherapy
8+ hour, 27+ min ago (1157+ words) Early stress in mitochondria before birth helped mouse hearts resist later chemotherapy damage by creating lasting protective changes. Chemotherapy can save lives, but some drugs can also put the heart under serious strain. Doxorubicin, a chemotherapy used against several cancers,…...
One Amino Acid Decides Whether Mitochondria Keep Their Protein Machines
4+ hour, 57+ min ago (75+ words) Mitochondria are the power stations of the cell, but they are also among the most dependent organelles in biology. The vast majority of the roughly one thousand proteins that make up a working mitochondrion are manufactured outside the organelle, in…...
Lipid Metabolism Emerges as a Central Driver of Drug Resistance in
5+ hour, 23+ min ago (71+ words) Aggressive non-Hodgkin lymphoma remains one of the most stubborn challenges in modern hematology. Even with a therapeutic arsenal that now includes rituximab-based immunochemotherapy, targeted kinase inhibitors, immune checkpoint blockade, and chimeric antigen receptor T-cell therapies, a substantial fraction of patients…...