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News
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
1+ hour, 12+ min ago (55+ words) The innate immune system is built on a paradox: the same molecular machinery that defends the body against infection can, when mishandled, turn that defense against the body itself. Few proteins embody this tension as vividly as NLRP6, a human pattern-recognition…...
One Amino Acid Decides Whether Mitochondria Keep Their Protein Machines
4+ hour, 3+ min ago (75+ words) Mitochondria are the power stations of the cell, but they are also among the most dependent organelles in biology. The vast majority of the roughly one thousand proteins that make up a working mitochondrion are manufactured outside the organelle, in…...
Protein Assembly, Not Abundance, Explains Why Cells Behave So Differently
5+ hour, 8+ min ago (689+ words) For decades, biologists have treated protein abundance as the closest available proxy for what a cell is actually doing. Measure how much of each protein a cell produces, the reasoning went, and you have a reasonable snapshot of its functional…...
Epigenetic Switches Could Arm Rice Against Its Deadliest Pathogens
5+ hour, 47+ min ago (679+ words) Rice feeds more than half of humanity, yet every harvest season it fights a silent war against two devastating enemies: the fungus Magnaporthe oryzae, which causes rice blast, and the bacterium Xanthomonas oryzae pv. oryzae, the agent of bacterial blight....
Cryo-EM Reveals the Dynamic Machinery That Switches Genes On
8+ hour, 52+ min ago (83+ words) Every cell in the human body carries the same genome, yet a neuron, a hepatocyte, and an immune cell behave in utterly different ways. The difference lies in which genes are switched on, when, and where. That act of switching,…...
NINJ1: The Membrane-Rupturing Protein That Decides How Cells Die and How
9+ hour, 9+ min ago (99+ words) Every day, billions of cells in the human body die in a controlled and deliberate fashion, a process that scientists have come to call regulated cell death. Far from being a simple collapse, many of these deaths culminate in a…...
Cohesin Builds Molecular Fences That Keep Active Genome Domains From Mixing
9+ hour, 16+ min ago (83+ words) Inside the nucleus of every human cell, roughly two meters of DNA are packed into a space only a few micrometers across, and how that packing is organized has profound consequences for health and disease. A new study published in…...
Newly Identified GPCR-Like Protein TM184C Controls Cellular Exchange and
10+ hour, 30+ min ago (850+ words) A protein called TM184C has emerged as an unexpected player in two of the most fundamental processes in cellular life: the movement of materials between cells and the controlled recycling of a cell’s own internal components....
Autophagy Protein AMBRA1 Unlocks NLRP3 Inflammasome Activation
10+ hour, 42+ min ago (737+ words) The NLRP3 inflammasome has long been one of immunology’s most consequential and most guarded molecular machines. Sitting inside macrophages and monocytes, this multi-protein complex acts as a tripwire for cellular danger, responding to an astonishingly diverse array of threats ranging from…...
Machine Learning Reads Genome Sequences to Reveal Hidden Microbial
12+ hour, 11+ min ago (651+ words) Symbiosis is one of the most consequential forces in the history of life. Bacteria and archaea that live in intimate association with host organisms have shaped the evolution of animals, plants, fungi and protists, driving innovations ranging from nitrogen fixation…...