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News
News: UNCOVERseq Exposes Off-Targets Missed by Established Standards
4+ hour, 18+ min ago (379+ words) An new end-to-end nomination workflow improves the nomination of genomic sites that may be unintentionally edited by CRISPR-Cas, combining high analytical sensitivity with a comparatively manageable list of candidates for confirmation. Tests in cell lines and human HSPCs suggest clinical…...
cGAS-Deficient Mice Show Premature Aging Linked to LINE1 Derepression and
43+ min ago (752+ words) A new study published in Nature Aging reports that mice lacking the enzyme cGAS develop signs of premature aging, accompanied by the abnormal activation of repetitive genetic sequences known as LINE1 elements and a rise in inflammation....
Koala Populations Show Geographic Variation in Toll-Like Receptor Diversity
5+ hour, 18+ min ago (733+ words) Koalas may carry more genetic variation in a crucial first line of immune defence than previously recognised, according to a new study of 413 wild animals sampled across eastern Australia....
Plant Cross-Incompatibility Limits Genome Exchange and Gene Pool
8+ hour, 39+ min ago (878+ words) Crop wild relatives may hold the genetic tools needed to help agriculture withstand drought, heat, salinity, emerging diseases and increasingly unstable growing conditions. Yet the same evolutionary distance that preserved these valuable traits often prevents breeders from moving them into…...
East German Plant Genetics Pioneer Thomas Börner Celebrates 80th Birthday
8+ hour, 47+ min ago (684+ words) A scientist who conducted molecular genetics research behind the Iron Curtain, built international collaborations before German reunification, and helped reveal how chloroplasts communicate with the cell nucleus is being celebrated as one of Germany’s pioneering plant geneticists. Professor Thomas Börner,…...
Pepper Study Links Ultra-Long Centromere Haplotypes to Evolution and
13+ hour, 8+ min ago (54+ words) Pepper plants may be hiding some of their most consequential genetic variation in regions long treated as difficult, repetitive stretches of DNA. A study published in Nature Ecology & Evolution reports that ultra-long haplotypes surrounding pepper centromeres can extend across tens…...
Scientists characterize genetic variants across the human intrinsically
13+ hour, 31+ min ago (656+ words) Variant effect prediction has entered a new phase, but one of biology’s largest blind spots remains stubbornly difficult to resolve. Computational tools have become increasingly effective at estimating the consequences of missense variants in folded protein domains, where amino-acid positions…...
Moving turtle nests to save the eggs can have hidden consequences
20+ hour, 28+ min ago (21+ words) Phys.org This site can’t be reached phys.org refused to connect....
Neuromorphic bionic eye with dense waveguide pixels enables tunable-depth
13+ hour, 55+ min ago (462+ words) 3D vision Bioengineer.org...
New Tool for Imaging Cristae Structure & Electrical Flickers
22+ hour, 58+ min ago (144+ words) Labroots New Tool for Imaging Cristae Structure & Electrical Flickers Visualizing the ultrastructure and dynamics of the inner mitochondrial membrane is a major challenge in mitochondrial research. Recently, researchers developed a new mitochondrial probe, HBmito Crimson, to capture the architecture, movement,…...