11+ min ago   (55+ words) Immunotherapy has transformed the outlook for people with advanced bladder and kidney cancer. Drugs known as immune checkpoint inhibitors, which block molecular brakes such as CTLA-4, PD-1 and PD-L1 to unleash the immune system against tumours, have dramatically improved long-term…...

32+ min ago   (53+ words) Triple-negative breast cancer is the form of the disease that clinicians fear most. Lacking the three molecular targets — the estrogen receptor, the progesterone receptor and the HER2 protein — that anchor modern targeted therapies, it leaves patients with fewer options and a…...

32+ min ago   (582+ words) Exercise is one of the most powerful medicines for the heart, enlarging cardiomyocytes in a healthy way and shielding the organ from the devastating damage that follows a heart attack. Yet the molecular arithmetic behind this benefit has remained stubbornly…...

48+ min ago   (571+ words) For patients diagnosed with small kidney cancers tucked dangerously close to the organ’s blood vessels, urine-collecting system, or neighboring bowel, treatment options have long been fraught with compromise. Surgery risks sacrificing precious kidney function, while conventional heat-based ablation risks burning…...

48+ min ago   (55+ words) Immune checkpoint inhibitors have rewritten the outlook for some patients with gastrointestinal cancers, turning once uniformly fatal diagnoses into manageable chronic conditions for a fortunate minority. Yet for every dramatic response there are many more patients whose tumours barely flinch,…...

48+ min ago   (758+ words) Scientists in Japan have taken one of the most detailed looks yet at how large-scale genome disruption inside tumor cells may quietly rewire the immune landscape around them, and their findings could help explain why some cancers mount virtually no…...

57+ min ago   (75+ words) Gastric cancer continues to rank among the most lethal malignancies worldwide, and a new study published in Medical Oncology has identified a molecular culprit that may explain how tumors in the stomach not only grow aggressively but also dismantle the…...

57+ min ago   (54+ words) Scientists in Sweden have confirmed that a single immune-related protein, measured in the cerebrospinal fluid that bathes the brain and spinal cord, falls steadily as Huntington’s disease advances — and that this decline mirrors how sick patients actually become. The protein,…...