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A practical guide to targeted single-cell RNA sequencing technologies - Communications Biology
10+ hour, 6+ min ago (1691+ words) We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to allow video information to be shared for both marketing, analytics…...
Long-term feeder cell-free cat intestinal organoid cultures to study Toxoplasma gondii’s sexual development - Communications Biology
10+ hour, 54+ min ago (1702+ words) We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to allow video information to be shared for both marketing, analytics…...
An experimentally-informed polymer model reveals high resolution organization of genomic loci - Nature Communications
1+ week, 4+ day ago (1674+ words) PyMOL 2.5.0 Open-Source, 2022-03-17 is used for visualization of 3D polymer configurations. Gnuplot 5.4 patchlevel 2 and Python libraries using conda environment are used for plotting. Keynotes are used for schematic figures. A combination of C and Python codes are used for all the analyses....
Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases - Nature Microbiology
2+ week, 4+ day ago (1679+ words) To determine the druggability of ASP2 and ASP3, we screened 24 aspartyl protease inhibitors, including compounds with known activity against P. falciparum PfPMIX and PfPMX, and clinical human beta-secretase inhibitors (Extended Data Fig. 6)22,75,76,77,78,79,80. A total of 16 compounds showed an IC50" Key reagents and resources used…...
Tree bark microbiota in climate-active gas cycling - Nature Reviews Microbiology
3+ week, 1+ day ago (248+ words) Tree bark microbiota in climate-active gas cycling'Nature Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or…...
haCCA: multi-module Integration of spot-based spatial transcriptomes and metabolomes - Communications Biology
4+ week, 21+ hour ago (728+ words) Vandereyken, K. et al. Methods and applications for single-cell and spatial multi-omics. Nat. Rev. Genet. 24, 494515 (2023). Argelaguet, R. et al. Computational principles and challenges in single-cell data integration. Nat. Biotechnol. 39, 12021215 (2021). Vicari, M. et al. Spatial multimodal analysis of transcriptomes and metabolomes in tissues. Nat....
Related microorganisms occupy similar ecological communities - Nature Ecology & Evolution
4+ week, 1+ day ago (123+ words) Nature Ecology & Evolution (2026)Cite this article Losos, J. B. Phylogenetic niche conservatism, phylogenetic signal and the relationship between phylogenetic relatedness and ecological similarity among species. Ecol. Lett. 11, 9951003 (2008). A review that discusses phylogenetic signal and niche conservatism. Eren, A. M. & Banfield, J. F. Modern microbiology: embracing complexity…...
A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci - Nature Communications
1+ mon, 16+ hour ago (1768+ words) Mouse ES cells were cultured in an ES cell medium comprising Knockout DMEM (Gibco), 1GlutaMAX-" (Gibco), 1MEM NEAA (Gibco), 100UmL1 penicillin (Wako), 100gmL1 streptomycin (Wako), 15% FBS (Gibco), 0.1mM mercaptoethanol (Nacalai Tesque), 1000UmL1 human LIF (Wako), 0.2M PD0325901 (Stemgent) and 3M CHIR99021 (Stemgent) on MEFs irradiated with X-ray. Peripheral blood was…...
Rapid evolution of a highly efficient RNA polymerase by homologous recombination
1+ mon, 1+ week ago (1719+ words) Nature Chemical Biology (2026)Cite this article The atomic coordinates and structure factors for the crystal structure of C28 have been deposited with the Research Collaboratory for Structural Bioinformatics (PDB ID: 9MYE). Other data are available in the main text and Supplementary Information section....
The sexual reproductive strategy in clonal Scopolia carniolica is based on obligatory cross-pollination and self-incompatibility
1+ mon, 1+ week ago (1718+ words) Studies of reproductive biology and pollination ecology are essential for predicting plant population survival1. The results can help to identify factors disturbing the reproduction of individuals and may be crucial for the implementation of conservation programs aimed at maintaining or restoring…...