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How cells recognize and repair DNA damage
3+ mon, 1+ week ago (380+ words) Of course, the cell is not powerless in the face of such lesions. It has an extensive catalog of cellular mechanisms that are set in motion following DNA damage. DNA damage response, or DDR for short, is the technical term…...
Your morning coffee could one day help fight cancer
6+ mon, 1+ week ago (560+ words) Chemogenetics involves directing cell behavior with small external molecules, often medications or dietary compounds, that activate specially engineered switches inside targeted cells. Unlike conventional drugs that can affect many tissues throughout the body, this method is designed to work only…...
A 25-year Crohn’s disease mystery finally cracked by AI
10+ mon, 1+ week ago (395+ words) Scientists at the University of California San Diego School of Medicine have created a new method that combines artificial intelligence (AI) with cutting-edge molecular biology tools to uncover what determines whether a macrophage becomes inflammatory or restorative. Their research also…...
CRISPR unlocks a new way to defeat resistant lung cancer
9+ mon, 3+ week ago (526+ words) Researchers at ChristianaCare's Gene Editing Institute have demonstrated that turning off the NRF2 gene with CRISPR technology can make lung cancer cells responsive to chemotherapy again. By blocking this gene, the treatment restores how tumors react to common cancer drugs and…...
A hidden mechanism changes what we know about cell division
9+ mon, 3+ day ago (827+ words) A companion study showed that centromeres, small structures on chromosomes once believed to work on their own, play a guiding role in directing CENP-E so it can help the division process unfold correctly. Together, these results overturn two decades of…...