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News
Scientists Flip the Drug Discovery Pipeline to Put Human Biology First in
49+ min ago (704+ words) Cardiovascular medicine is quietly undergoing a structural rethink, and the change begins with the order of operations....
Aptamer-Guided CRISPR-Cas9 Delivery Could Make Cancer Genome Editing
49+ min ago (55+ words) Gene editing has long promised a revolution in cancer medicine, yet the promise has remained stubbornly out of reach for one deceptively simple reason: getting the CRISPR-Cas9 machinery into tumor cells, and only tumor cells, is extraordinarily difficult. A new…...
AI Translates Light Microscopy Into Electron-Microscope Detail to Speed
49+ min ago (534+ words) Mapping the wiring of the brain at nanometer resolution has long demanded a punishing trade-off: electron microscopy can reveal every synaptic cleft and organelle, but imaging even a cubic millimeter of neural tissue this way takes months or years of…...
Proteomic Aging Clocks Enter the Clinic in Landmark Phase 2a Geroprotection
2+ hour, 46+ min ago (744+ words) For decades, the central obstacle to testing therapies that slow human aging has been painfully simple: aging takes decades to measure. A drug that genuinely delays the biological processes of aging would need years, often a lifetime, of follow-up before…...
Transposable Elements Drive the Birth of Vast Satellite DNA Repertoires in
3+ hour, 7+ min ago (597+ words) The genomes of true frogs have long puzzled geneticists. Amphibians are famous for carrying some of the largest and most repetitive genomes among vertebrates, and yet the detailed architecture of their repetitive DNA has remained poorly explored compared with mammals,…...
Cryoprotectant-Free Vitrification Leaves Hidden Molecular Marks on Human
3+ hour, 53+ min ago (653+ words) A new study comparing the two main ways of freezing human sperm has found that even when samples look equally healthy under the microscope, the proteins inside them tell a strikingly different story....
Waste Apples Turned Into Lactic and Succinic Acids at Pilot Scale
4+ hour, 43+ min ago (84+ words) Every year, a substantial share of the apples grown across Europe never reaches a consumer. The European Union harvested roughly 11.5 million tons of apples in 2023, yet estimates suggest that more than 20 percent is lost during primary production, with further losses…...
Mussel-Inspired Coating Keeps Tiny Artificial Lungs Clot-Free
5+ hour, 3+ min ago (676+ words) For the smallest and most fragile patients in intensive care, the difference between survival and decline often comes down to a few milliliters of oxygen. Preterm and term newborns who develop respiratory distress syndrome frequently need mechanical ventilation, and in…...
Engineered Bacterial Teams Turn Sunlight and CO2 Into 1-Butanol
5+ hour, 55+ min ago (350+ words) Scientists at Uppsala University have taken a significant step toward a long-sought goal in industrial biotechnology: using sunlight and carbon dioxide to feed engineered microbes that churn out valuable chemicals. In a study published in Applied Microbiology and Biotechnology, Stamatina…...
Mole-Rat Genes Evolving Faster Than Expected Reveal Secrets of Subterranean
6+ hour, 15+ min ago (568+ words) Beneath the sun-baked soils of eastern and southern Africa, a family of rodents has quietly rewritten the rules of mammalian life. Naked mole-rats resist cancer, tolerate near-anoxic conditions and barely age. Damaraland mole-rats dig elaborate tunnel networks and live in…...