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News
New Single-Molecule Technique Reads Intact Tau Proteins at Unprecedented
10+ hour, 42+ min ago (55+ words) Scientists have unveiled a powerful new method that allows researchers to measure intact protein forms, known as proteoforms, one molecule at a time and on a scale never before possible. The technique, called Iterative Mapping of proteoforms, was demonstrated on…...
Brain Gatekeeper Found to Ferry Serine That Builds Young Synapses
11+ hour, 33+ min ago (75+ words) A transporter sitting in the walls of the brain’s blood vessels has turned out to be one of the most important gatekeepers of brain chemistry during development, according to a new study published in iScience. The protein, known as SLC38A2, shuttles…...
Deep Learning Cuts Brain MRI Scans to Under 100 Seconds in Feasibility
12+ hour, 37+ min ago (764+ words) Magnetic resonance imaging has long been the gold standard for peering into the human brain, but it has always demanded one precious commodity that many patients simply cannot spare: time....
Gut Bacteria May Reveal Brain Aging Decades Before Symptoms Appear
13+ hour, 16+ min ago (636+ words) The earliest fingerprints of an aging brain may be visible not in memory lapses or mood changes, but in an unexpected place: the gut....
Exercise Is Safe for Neurodevelopmental Disorders, But Only If Trials
14+ hour, 55+ min ago (56+ words) Physical activity has become one of the most widely recommended interventions for people with neurodevelopmental disorders, a family of conditions that includes autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual developmental disorder, and specific learning, communication and motor disorders. Clinical guidelines…...
Brain-Wide Activity Ties Subcortical Decline to Spreading Tau in Early
16+ hour, 59+ min ago (542+ words) Alzheimer’s disease has long been portrayed as a story written in the cortex, the wrinkled outer layer of the brain where memory and thought reside. But a new study published in Nature Communications suggests that the opening chapters of that…...
Cognitive Strategy Training at Home Shows Very Large Effects After Brain
17+ hour, 9+ min ago (77+ words) For the millions of people who survive a stroke or traumatic brain injury each year, the most stubborn obstacles to recovery are often invisible. While paralysed limbs and unsteady gait attract immediate clinical attention, the cognitive aftershocks—faltering attention, scrambled…...
TIMP2 Protein Levels and Gene Variants Trace Ageing and Neurodegeneration
17+ hour, 22+ min ago (641+ words) A single protein long suspected of linking the ageing brain to neurodegenerative disease is stepping into the spotlight....
Right Temporal Dementia Disrupts the Brain’s Emotional Signature Networks
18+ hour, 4+ min ago (672+ words) Frontotemporal dementia has long been described as a disease of personality and language, but one of its rarest and most elusive forms has remained stubbornly difficult to characterize....
Polyubiquitin Repositioning Reshapes Pathological Tau Fibril Structures in
18+ hour, 36+ min ago (668+ words) The pathological proteins that accumulate in the aging human brain are not amorphous debris. They are highly ordered molecular assemblies, and their precise atomic architecture can determine which neurodegenerative disease a patient develops, how fast it progresses, and how it…...