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News
Antibody-Drug Combination Falls Short in First-Line PD-L1-High Metastatic
8+ hour, 3+ min ago (650+ words) A closely watched Phase 3 clinical trial has delivered a sobering verdict on one of the most anticipated treatment strategies in lung cancer medicine....
Scientists Flip the Drug Discovery Pipeline to Put Human Biology First in
8+ hour, 37+ min ago (704+ words) Cardiovascular medicine is quietly undergoing a structural rethink, and the change begins with the order of operations....
AI That Learns the Rules: Symbolic Neural Generators Design New Drug
9+ hour, 10+ min ago (90+ words) Artificial intelligence has become an increasingly powerful tool in the search for new medicines, but a persistent problem has haunted the field: neural networks that invent molecules are remarkably creative yet notoriously unreliable. They can propose chemical structures that look…...
Bispecific Antibody Meets Antibody-Drug Conjugate in Promising Small Cell
11+ hour, 39+ min ago (770+ words) Small cell lung cancer has long been one of the most difficult malignancies to treat, marked by aggressive growth, early dissemination and a stubborn tendency to develop resistance to standard therapies....
Plant Compound Diosgenin Emerges as Powerful Computational Anti-Cancer
16+ hour, 16+ min ago (698+ words) Cancer remains one of the most formidable health challenges of the modern era, claiming millions of lives each year despite decades of therapeutic advances....
Polyubiquitin Repositioning Reshapes Pathological Tau Fibril Structures in
16+ hour, 48+ min ago (668+ words) The pathological proteins that accumulate in the aging human brain are not amorphous debris. They are highly ordered molecular assemblies, and their precise atomic architecture can determine which neurodegenerative disease a patient develops, how fast it progresses, and how it…...
Beyond KRAS G12C: New Drug Wave Targets Once-Undruggable Cancer Driver
17+ hour, 46+ min ago (584+ words) KRAS has long been the most notorious villain in cancer genetics. The gene, formally known as Kirsten rat sarcoma viral oncogene homolog, is mutated in nearly all pancreatic ductal adenocarcinomas, a large share of colorectal cancers, and a significant fraction…...
Antibody-Drug Conjugate Hits Recommended Phase 3 Dose in EGFR-Mutated Lung
20+ hour, 59+ min ago (832+ words) An investigational antibody-drug conjugate that simultaneously targets two of the most important growth-driving proteins in lung cancer has delivered encouraging clinical results in patients whose tumors had already resisted modern targeted therapy, according to data presented at the International Association…...
Ruxolitinib Shows Stronger Response in Primary Than Secondary HLH,
21+ hour, 32+ min ago (632+ words) Hemophagocytic lymphohistiocytosis is one of the most feared syndromes in medicine, a runaway immune firestorm in which the body’s own scavenger cells turn against blood cells and organs, and it can kill within weeks if untreated....
Scientists Discover How a Widely Used Cancer Drug Is Made in Nature
21+ hour, 58+ min ago (558+ words) For six decades, one of medicine’s most important anticancer drugs has kept a remarkable secret. 5-Azacytidine, a nucleoside analogue used to treat myelodysplastic syndrome, a group of blood cancers, was first synthesized in a laboratory in the 1960s and only later…...