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News
Gut Bacteria May Reveal Brain Aging Decades Before Symptoms Appear
1+ day, 10+ hour ago (636+ words) The earliest fingerprints of an aging brain may be visible not in memory lapses or mood changes, but in an unexpected place: the gut....
SIRT1 Silences Jumping Genes by Stabilizing Heterochromatin Complexes
1+ day, 13+ hour ago (55+ words) Deep within the human genome lies an ancient threat. Long interspersed elements-1, known as LINE-1 or L1, are the only autonomous transposable elements still active in our DNA, making up roughly 17 percent of the genome. When these genetic parasites leap to…...
Cryo-EM Reveals the Dynamic Machinery That Switches Genes On
1+ day, 18+ hour ago (83+ words) Every cell in the human body carries the same genome, yet a neuron, a hepatocyte, and an immune cell behave in utterly different ways. The difference lies in which genes are switched on, when, and where. That act of switching,…...
Metabolism Holds the Key to the Senescence Secretome
1+ day, 23+ hour ago (634+ words) Cellular senescence has long been described as a state of permanent growth arrest, a kind of biological emergency brake that stops damaged or stressed cells from dividing. But researchers have increasingly come to appreciate that the arrested cell is anything…...
CRISPR Methylation Editing Rewrites the Cancer Epigenome Toward Causation
2+ day, 5+ hour ago (67+ words) Cancer has long been understood as a disease of the genome, driven by mutations that rewire the instructions encoded in DNA. Over the past three decades, however, a parallel truth has crystallized: cancer is equally a disease of the epigenome,…...
How Epigenetics Is Rewriting the Philosophy of Harm and Benefit
3+ day, 12+ hour ago (757+ words) A concept as old as moral philosophy itself is being shaken by one of modern biology’s most transformative fields. In a new analysis published in Epigenetics Communications, philosopher Agnes E....
Single-cell maps reveal how enhancers regulate their target genes
4+ day, 2+ hour ago (846+ words) Genomic dark matter has long been the paradox at the heart of human genetics....
MED1 shapes cancer gene expression in a context-dependent manner
6+ day, 4+ hour ago (665+ words) In the dense machinery of gene regulation, few molecules have proven as paradoxical as MED1, a subunit of the Mediator complex that serves as a molecular bridge between transcription factors and RNA polymerase II....
How Maternal Severe Illness During Pregnancy Can Impair Fetal Brain
6+ day, 7+ hour ago (819+ words) Roughly one in ten Americans lives with a neurodevelopmental condition, yet for decades scientists have struggled to answer a deceptively simple question: where, when, and how do these disorders begin? A new study from the Salk Institute for Biological Studies,…...
Multi-omics reveals chromatin states governing tendon cell homeostasis
1+ week, 14+ hour ago (744+ words) The humble tendon, that rope-like tissue anchoring muscle to bone, has long kept its molecular secrets hidden. Now a team of researchers in China has pulled back the curtain on the epigenetic machinery that defines tenocytes, the specialized cells responsible…...