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News
Engineered E. coli swarms record chemical and light inputs in visible
1+ day, 5+ hour ago (521+ words) Bacteria are famous for forming patterns, from the concentric rings of Proteus colonies to the branching networks that motile microbes paint across agar plates. Now researchers at Columbia University have turned one of biology’s most familiar workhorses, Escherichia coli, into…...
Collagen Switch Turns Fish Fins Into Limb-Like Structures
1+ day, 12+ hour ago (83+ words) When the first fish lineage crawled onto land some 375 million years ago, its fins had to be remodeled into limbs capable of bearing weight. Evolutionary biologists have long focused on the genes that pattern the skeleton—Hox clusters, Sonic hedgehog,…...
Stowers Institute partners with Google DeepMind and leading research institutions to help reveal the regulatory language of the human genome
5+ day, 12+ hour ago (750+ words) Researchers provided biological expertise and feedback that helped guide the development of a new AI-powered resource released today. For the first time, scientists can explore a comprehensive map of more than 9 billion possible single-letter DNA changes Credit: Stowers Institute for…...
MissenseHMM annotates missense variants by jointly modeling pathogenicity
1+ week, 1+ day ago (769+ words) Every day, laboratories and clinics around the world generate genetic sequences in which a single letter of the DNA code has been swapped for another, and many of these changes alter the amino acid composition of the proteins those genes…...
Hybrid nanofluid blood flow modeled in ciliated porous concentric tubes
1+ week, 3+ day ago (754+ words) Cilia are tiny, whip-like filaments that line many of the body’s internal passages, and when they beat in coordinated waves they can push fluid along without any external pump....
Gene family evolution and salivary gene expression track diet shifts in
1+ week, 3+ day ago (758+ words) Aphids draining sap from a rose bush, bedbugs feeding on human blood, assassin bugs skewering prey, and water striders hunting insects on the surface of a pond all belong to a single insect order, Hemiptera....
How Design, Modeling, and Spatial Analysis Shape Genomic Selection
2+ week, 2+ day ago (71+ words) Plant breeders may be able to test far more crop varieties without sacrificing the accuracy of genomic predictions, according to a large simulation study spanning maize, sunflower and oat. The research found that partially replicated field designs—plots in which…...
Mapping gene and epigenetic changes that make undead cancer cells promote
3+ week, 3+ day ago (581+ words) Cancer treatments that stop tumors from growing may also leave behind a potentially dangerous population of “undead” cells, according to a new study from researchers at The Rockefeller University....
Schisandrin Lignans Stabilize GPX4 to Suppress Ferroptosis in Drug-Induced
3+ week, 6+ day ago (57+ words) Drug-induced liver injury, one of the most unpredictable complications of modern pharmacotherapy, may be driven by a molecular failure that scientists are now learning to prevent. A study by Lan, Zheng, Li and colleagues reports that schisandrin lignans—bioactive compounds…...