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News
New Sequencing Method Maps RNA Isoforms Across Brain Cells With Single-Cell
1+ day ago (529+ words) Every cell in the brain carries essentially the same genome, yet the same gene can produce a startling variety of RNA molecules. Through a process called alternative splicing, segments of a gene’s transcript can be included, skipped, or rearranged, generating…...
AI Graph Tool scFormer Uncovers Rare Cell States Hidden in Single-Cell and
1+ day, 4+ hour ago (75+ words) Rare cells punch far above their weight in biology. Populations that make up less than one percent of a tissue can drive tumor progression, immune evasion, drug resistance, and relapse, while others mark the first steps of lineage commitment or…...
DartUniFrac Brings Megascale Computing to Microbiome Diversity Analysis
1+ day, 6+ hour ago (512+ words) Researchers have introduced DartUniFrac, a new software tool designed to carry out UniFrac-based microbiome comparisons at a scale that was previously impractical....
Nanoparticles Emerge as a Powerful New Weapon Against Cellular Aging
1+ day, 8+ hour ago (87+ words) Cellular senescence, one of the most closely studied hallmarks of aging, has long been a paradox in biology. On the one hand, it protects organisms by halting the division of damaged cells that might otherwise become cancerous. On the other,…...
New AI Framework SCIGMA Unifies Spatial Multiomics Data With Built-In
1+ day, 8+ hour ago (674+ words) Spatial omics technologies have transformed biology by allowing scientists to measure gene expression, proteins, chromatin states and even metabolites directly within intact tissue sections, preserving the geographical context that single-cell methods discard....
Transfer Learning Reconstructs the Signaling Histories of Single Cells
1+ day, 10+ hour ago (704+ words) Every cell in the body carries a hidden biography. Long before a researcher harvests a tissue and sequences its contents, that cell has been bombarded by hormones, growth factors, cytokines and stress signals, and its current state is the accumulated…...
Prime Editing Gets a Size Upgrade: Researchers Insert Large DNA Fragments
1+ day, 11+ hour ago (653+ words) The gene-editing field has long faced a stubborn trade-off. Tools such as CRISPR-Cas9 excel at cutting DNA and at making small, targeted changes, but installing large pieces of genetic material into a genome at a precise location — without causing collateral…...
Dual-State Structures Reveal How Drugs Switch the Immune Receptor GPR84
1+ day, 13+ hour ago (69+ words) A receptor long viewed as one of the more enigmatic members of the lipid-sensing G protein-coupled receptor family is now coming into sharp molecular focus. New research published in Experimental & Molecular Medicine describes how structural snapshots of GPR84, captured in distinct…...
New Computational Framework Tracks Cell Migration Across Space and Time
1+ day, 23+ hour ago (879+ words) Scientists have unveiled a new computational framework that brings together two of the most powerful technologies in modern biology—single-cell RNA sequencing and spatial transcriptomics—to reconstruct how populations of cells redistribute and change state across time within living tissues....
Genetic Suppressors Rescue Tubulin Mutations and Restore Microtubule
1+ day, 23+ hour ago (757+ words) Microtubules are among the most essential structures in any cell, hollow filaments built from α- and β-tubulin dimers that provide mechanical scaffolding, act as railways for intracellular transport, and form the spindle apparatus that segregates chromosomes during division. When the…...