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News
AI Translates Light Microscopy Into Electron-Microscope Detail to Speed
46+ min ago (534+ words) Mapping the wiring of the brain at nanometer resolution has long demanded a punishing trade-off: electron microscopy can reveal every synaptic cleft and organelle, but imaging even a cubic millimeter of neural tissue this way takes months or years of…...
BenchHub Turns Computational Biology Benchmarking Into a Living,
1+ hour, 39+ min ago (618+ words) Every day, computational biologists release new methods for analyzing genomes, single cells, microbiomes and molecular signatures, and every day researchers struggle with the same question: which method actually works best for their data? The answer usually depends on benchmarks—structured…...
New AI Pipeline Turns Tangled 3D Brain Videos into Clear Neuronal Activity
3+ hour, 50+ min ago (529+ words) Neuroscientists can now record electrical storms of activity from tens of thousands of neurons at once, but a stubborn bottleneck has long stood between the raw data and discovery: turning enormous three-dimensional calcium imaging videos into clean, trustworthy lists of…...
MemBrain v2 Brings End-to-End Membrane Analysis to Cryo-Electron Tomography
6+ hour, 41+ min ago (880+ words) Cryо-electron tomography has quietly become one of the most powerful windows into the interior of cells, allowing researchers to peer at the molecular machinery of life in a state close to its native, frozen-hydrated condition....
Hierarchical AI model unifies single-cell multiomics data through deep
2+ day, 20+ hour ago (829+ words) Researchers at the Indian Institute of Technology Kanpur, working with a collaborator at the University of California, Irvine, have unveiled a new artificial intelligence framework that promises to make sense of one of the most data-rich but technically unruly corners…...
Human long noncoding RNA localization is isoform-specific, obscured by
2+ week, 3+ day ago (754+ words) gene-level analysis Bioengineer.org...
New Tool for Imaging Cristae Structure & Electrical Flickers
2+ week, 4+ day ago (144+ words) Labroots New Tool for Imaging Cristae Structure & Electrical Flickers Visualizing the ultrastructure and dynamics of the inner mitochondrial membrane is a major challenge in mitochondrial research. Recently, researchers developed a new mitochondrial probe, HBmito Crimson, to capture the architecture, movement,…...
Constructing Digital Twin Brains Beyond Measurement Limits
1+ mon, 2+ day ago (502+ words) The idea of creating a digital copy of the human brain has long belonged more to science fiction than to working biology....
Chlamydomonas chlororibosome reshaped by chloroplast-encoded small subunit
1+ mon, 2+ week ago (421+ words) Chlamydomonas chlororibosome architecture mapped by cryo-ET and purified ribosome cryo-EM A new report in Nature Plants combines in situ cryo-electron tomography with high-resolution single-particle cryo-EM to reveal how chloroplast ribosomes in Chlamydomonas reinhardtii are reshaped by a small-subunit extension encoded…...
TSPAN7 Builds Transmembrane Skeleton, Stabilizing Tubular Membranes via
1+ mon, 3+ week ago (328+ words) Tetraspanins are four-transmembrane proteins best known for organizing cell membranes into specialized microdomains that recruit lipids and partner proteins. Over the past few years, several tetraspanins have also been shown to form ordered polymer assemblies, raising the possibility that these…...