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Whole-Body Proteome Atlas Reveals 41 Potential Cancer Drug Targets
3+ week, 5+ hour ago (575+ words) how the proteome changes during oncogenesis and isolated 41 low-toxicity destinations for targeted drugs...Tissue-specific expression of protein drug targets might contribute to off-target effects, leading the...authors to map 402 tissue-specific targets to 2,598 drugs....High target concentration in the liver could…...
Schisandrin Lignans Stabilize GPX4 to Suppress Ferroptosis in Drug-Induced
3+ week, 6+ day ago (57+ words) Drug-induced liver injury, one of the most unpredictable complications of modern pharmacotherapy, may...
Dual-State Structures Reveal How Drugs Switch the Immune Receptor GPR84
1+ day, 19+ hour ago (69+ words) A receptor long viewed as one of the more enigmatic members of the lipid-sensing G protein-coupled receptor family is now coming into sharp molecular focus. New research published in Experimental & Molecular Medicine describes how structural snapshots of GPR84, captured in distinct…...
Chemists forge chiral piperidine mimics in a single asymmetric leap
2+ day, 5+ hour ago (904+ words) Medicinal chemists have long chased a deceptively simple goal: build drug candidates that are less flat...
Designing Better Biomedical Hydrogels Through Molecular Building Blocks and
3+ week, 2+ day ago (561+ words) precisely engineered miniature landscapes, with organized structures that control how forces, water, ions, drugs...
Computational study reveals how ketoprofen interacts with biomolecules
1+ week, 1+ day ago (894+ words) Ketoprofen, one of the most widely prescribed nonsteroidal anti-inflammatory drugs in the world, has...
Proteomic Aging Clocks Enter the Clinic in Landmark Phase 2a Geroprotection
1+ day, 10+ hour ago (744+ words) A drug that genuinely delays the biological processes of aging would need years, often a lifetime, of...
Stanford study shows molecular glue converts cancer driver into built-in
3+ week, 2+ day ago (593+ words) A two-headed experimental drug has eradicated aggressive human lymphoma tumors in mice by turning one...
AI Graph Tool scFormer Uncovers Rare Cell States Hidden in Single-Cell and
1+ day, 11+ hour ago (75+ words) Populations that make up less than one percent of a tissue can drive tumor progression, immune evasion, drug...
Nanoparticles Emerge as a Powerful New Weapon Against Cellular Aging
1+ day, 14+ hour ago (87+ words) accumulating in tissues over decades and releasing a flood of […] Subject of Research: Nanoparticle-based drug...