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News
Plant discovery could lead to new ways of producing medicines
7+ mon, 4+ week ago (511+ words) Scientists have shown how plants produce powerful natural chemicals that could help in the production of new medicines in more environmentally friendly ways. Plants make substances called alkaloids to protect themselves, and humans have long taken advantage of these chemicals,…...
UPLC-MS/MS Method for Asciminib and Shikonin Analysis
9+ mon, 2+ week ago (890+ words) In a groundbreaking study published in BMC Pharmacology & Toxicology, researchers from China have developed a novel ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method that represents a significant advancement in the quantification of asciminib, a promising drug in the…...
Innovative Analytical Technique Uncovers Drug Combination Effects in
5+ mon, 1+ week ago (1306+ words) Acute myeloid leukemia (AML) continues to present an immense challenge in oncology due to its aggressive nature and resistance to conventional therapies. Despite advances in drug development, combinatorial drug regimens have often outperformed monotherapies in clinical settings, yet the intricate…...
Scientists turned a tiny parasite into a living drug factory
3+ mon, 3+ day ago (866+ words) Rewriting a hookworm’s DNA had long remained out of reach. The worm’s tough outer coating, its complex life cycle, and its poorly characterized genome kept it beyond the reach of gene-editing tools that work reliably in bacteria, mice, and human…...
Advancements in Activity-Based Profiling for Natural Products
11+ mon, 2+ week ago (901+ words) Recent advancements in the field of proteomics have opened up new avenues for understanding the interactions between proteins and small molecules, particularly in the context of natural products. In a groundbreaking study titled “Progress and application of activity-based protein profiling…...
A direct-to-biology approach to streamline PROTAC synthesis and profiling
11+ mon, 5+ day ago (610+ words) Figure 1. Overview of the automated D2B platform developed at Charnwood allowing high-throughput PROTAC hit finding and rapid SAR generation. Image Credit: Concept Life Sciences D2B is a semi-automated process that allows fast biological assessment of crude reaction mixtures within a plate, shortening…...
Space research helping fight against drug-resistant superbugs
7+ mon, 4+ week ago (428+ words) Research in space could help fight drug-resistant superbugs such as E. coli, say scientists. An experiment partially conducted on board the International Space Station (ISS) showed that viruses and bacteria interact differently in microgravity. Researchers found that terrestrial bacteria-infecting viruses were…...
Unraveling Momordin Ic’s Impact on Stp1 Activity
10+ mon, 4+ day ago (820+ words) In a groundbreaking study, researchers have embarked on an extensive investigation into the inhibitory mechanisms of momordin Ic, a compound derived from the seeds of the Momordica charantia plant, against the serine/threonine phosphatase (Stp1) enzyme found in Staphylococcus aureus. This…...
Profiling Biology at Scale with DRUG-seq: From Mechanisms to Safety, Upcoming Webinar Hosted by Xtalks
10+ mon, 2+ week ago (351+ words) Traditional discovery approaches force a trade-off: deep biological resolution for a few perturbations or broad screens with limited endpoints. This webinar explores how a high-throughput transcriptomics assay addresses this challenge by enabling genome-wide expression profiling at an industrial scale, supporting…...
New Antivenom Demonstrates Efficacy Against 17 African Snake Species
10+ mon, 2+ week ago (867+ words) A groundbreaking development in the world of venomous snakebite treatment has emerged from researchers at the Technical University of Denmark (DTU). For decades, the global health community has grappled with the challenge of producing antivenoms that effectively neutralize the toxins…...