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Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells | Nature Biotechnology
11+ hour, 54+ min ago (710+ words) Nature Biotechnology (2026) Cite this article The luciferase activity was measured using a Dual-Luciferase Reporter Assay System (Promega) according to the manufacturer’s protocol. All assays were performed in white 96-well plates (Sangon Biotech, 400 µl, high adsorption) with a SuperMax 3000AL luminometer (Flash…...
Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens | Nature Microbiology
1+ mon, 3+ day ago (1722+ words) Randow, F., MacMicking, J. D. & James, L. C. Cellular self-defense: how cell-autonomous immunity protects against pathogens. Science 340, 701–706 (2013). Vaishnava, S. et al. The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255–258 (2011). Chen, R. et al. Pattern recognition receptors: function,…...
Groundwater microbial communities across the terrestrial subsurface - Nature Microbiology
1+ mon, 1+ week ago (1692+ words) Nature Microbiology (2026) Cite this article Kallmeyer, J., Pockalny, R., Adhikari, R. R., Smith, D. C. & D’Hondt, S. Global distribution of microbial abundance and biomass in subseafloor sediment. Proc. Natl Acad. Sci. USA 109, 16213–16216 (2012). Magnabosco, C. et al. The biomass and biodiversity of the continental subsurface. Nat. Geosci....
Echoes in the earth: how microbiomes help plants remember and resist - Nature Reviews Microbiology
1+ mon, 2+ week ago (157+ words) Nature Reviews Microbiology (2026) Cite this article In this Genome Watch, we explore how the ecological memory of microbiomes shapes transgenerational stress resilience in plants. Liang, S. et al. Climate-influenced ecological memory modulates microbial response to soil moisture. Glob. Change Biol. 31, e70099 (2025). Jobert,…...
In vitro model of the human embryonic disc takes flight - Nature Structural & Molecular Biology
1+ mon, 2+ week ago (391+ words) In vitro model of the human embryonic disc takes flight Nature Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up…...
Universal cell embedding provides a foundation model for cell biology
1+ mon, 3+ week ago (1688+ words) Nature (2026) Cite this article UCE is trained in a fully self-supervised manner, without using any cell type or dataset-based annotations. While incorporating cell type labels into the model design or training could seem advantageous, it is preferable for the organization…...
U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations | Nature Genetics
2+ mon, 1+ day ago (1722+ words) Nature Genetics (2026) Cite this article This study does not report custom code or software. Software packages used are described within the appropriate Methods subsections and in the Reporting Summary. Yoshida, K. et al. Frequent pathway mutations of splicing machinery in myelodysplasia....
Why the temporal dimension matters in cellular signalling - Nature Cell Biology
2+ mon, 2+ day ago (396+ words) Nature Cell Biology (2026) Cite this article Temporal encoding of signalling dynamics is not just widespread; it offers a fundamental information-theoretic advantage in cellular communication. Recent advances in channel capacity measurement and decoding of second-messenger networks now provide a predictive framework…...
Genome-wide absolute quantification of chromatin looping | Nature Structural & Molecular Biology
2+ mon, 2+ day ago (1728+ words) Nature Structural & Molecular Biology (2026) Cite this article Dekker, J. & Mirny, L. A. The chromosome folding problem and how cells solve it. Cell 187, 6424–6450 (2024). Yang, J. H. & Hansen, A. S. Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation. Nat. Rev....
Putting numbers on chromatin looping - Nature Structural & Molecular Biology
2+ mon, 2+ day ago (234+ words) Nature Structural & Molecular Biology (2026) Cite this article Chromatin looping is a fundamental feature of genome organization that contributes to gene regulation and genome stability. Yet how often loops form in living cells has remained difficult to answer. Jusuf et al....