11+ hour, 16+ min ago  (282+ words) Nature Structural & Molecular Biology (2026)Cite this article METALoci, a computational framework to study the 3D genome, reveals a prominent rewiring of regulatory interactions during sex determination. This geostatistics-inspired method also uncovered a previously unknown non-coding regulatory region at the Fgf9 locus and…...

11+ hour, 47+ min ago  (336+ words) Overcoming cytoskeleton instability in the early embryo'Nature Your privacy, your choice We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as…...

2+ week, 3+ day ago  (118+ words) Nature Reviews Molecular Cell Biology (2026)Cite this article Straub, M. S. et al. Laser flash melting cryo-EM samples to overcome preferred orientation. Nat. Methods 22, 18801886 (2025) Institute of Chemical Sciences and Engineering ISIC, EPFL, Lausanne, Switzerland Correspondence to Constantin R. Kr'ger. A patent has been…...

2+ week, 6+ day ago  (1691+ words) We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to allow video information to be shared for both marketing, analytics…...

2+ week, 6+ day ago  (1702+ words) We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to allow video information to be shared for both marketing, analytics…...

1+ mon, 2+ day ago  (1674+ words) PyMOL 2.5.0 Open-Source, 2022-03-17 is used for visualization of 3D polymer configurations. Gnuplot 5.4 patchlevel 2 and Python libraries using conda environment are used for plotting. Keynotes are used for schematic figures. A combination of C and Python codes are used for all the analyses....

1+ mon, 1+ week ago  (1679+ words) To determine the druggability of ASP2 and ASP3, we screened 24 aspartyl protease inhibitors, including compounds with known activity against P. falciparum PfPMIX and PfPMX, and clinical human beta-secretase inhibitors (Extended Data Fig. 6)22,75,76,77,78,79,80. A total of 16 compounds showed an IC50" Key reagents and resources used…...

1+ mon, 2+ week ago  (248+ words) Tree bark microbiota in climate-active gas cycling'Nature Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or…...

1+ mon, 2+ week ago  (728+ words) Vandereyken, K. et al. Methods and applications for single-cell and spatial multi-omics. Nat. Rev. Genet. 24, 494515 (2023). Argelaguet, R. et al. Computational principles and challenges in single-cell data integration. Nat. Biotechnol. 39, 12021215 (2021). Vicari, M. et al. Spatial multimodal analysis of transcriptomes and metabolomes in tissues. Nat....

1+ mon, 3+ week ago  (123+ words) Nature Ecology & Evolution (2026)Cite this article Losos, J. B. Phylogenetic niche conservatism, phylogenetic signal and the relationship between phylogenetic relatedness and ecological similarity among species. Ecol. Lett. 11, 9951003 (2008). A review that discusses phylogenetic signal and niche conservatism. Eren, A. M. & Banfield, J. F. Modern microbiology: embracing complexity…...