23+ hour, 21+ min ago   (144+ words) Labroots New Tool for Imaging Cristae Structure & Electrical Flickers Visualizing the ultrastructure and dynamics of the inner mitochondrial membrane is a major challenge in mitochondrial research. Recently, researchers developed a new mitochondrial probe, HBmito Crimson, to capture the architecture, movement,…...

1+ day, 23+ hour ago   (421+ words) EasyGrid Simplifies Cryo-Electron Microscopy Sample Preparation Labroots EasyGrid Simplifies Cryo-Electron Microscopy Sample Preparation A new method published in Nature Methods removes much of the guesswork and time-consuming optimization from sample preparation for cryo-electron microscopy and tomography (cryo-EM/ET). To image…...

3+ week, 5+ day ago   (497+ words) Tumors Dysregulate Immune Cells in the Thymus Labroots Tumors Dysregulate Immune Cells in the Thymus The immune system is made up of a wide range of cells to fight off disease. Each cell works in an orchestrated fashion to achieve…...

1+ mon, 1+ week ago   (375+ words) A Fungus & Bacterium Have a Symbiosis that Changes the Severity of Fungal Disease This study was based on samples of P. griseola that were obtained from Puerto Rico, Honduras, Guatemala, and Tanzania. The investigators isolated and sequenced DNA from these samples…...

3+ mon, 1+ week ago   (226+ words) Proteins typically have a three-dimensional structure and are made up of strings of amino acids. But an amino acid string needs to only be a certain length, and have a likely biological role to be considered a protein. But it…...

3+ mon, 3+ week ago   (367+ words) One particular multicellular cyanobacterium that has been studied for decades is known as Anabaena sp. PCC 7120. Researchers have shown that there has been a significant evolutionary change in this microbe that has taken an ancient process for segregating DNA during…...

4+ mon, 4+ day ago   (219+ words) Previous work by Douglas and colleagues indicated that NHR-49 monitors intracellular lipid stores too, and triggers a process to prevent cells from starving if lipid supplies run low. The researchers eliminated NHR-49 expression in C. elegans, and withheld food from the…...

4+ mon, 2+ week ago   (232+ words) The protein characterized in this study works as a ‘molecular shredder’ that eliminates RNA transcripts; these are created by the cell when an active gene should be made into protein. But the molecular shredder known as ESB2 can destroy RNA, even…...

4+ mon, 3+ week ago   (233+ words) "Everyone always wants to know how temperature sensing works, but it turns out to be a very technically challenging question to answer," said Julius, co-corresponding study author and Chair of Molecular Biology and Medicine, and of Physiology at the University…...

5+ mon, 1+ day ago   (376+ words) Why validate after protein purification When combined with the Amersham™ ImageQuant™ 800 Western blot imaging system and ImageQuant™ TL analysis software, researchers can quickly perform quantitative densitometry to determine whether the purification was satisfactory or whether further optimization is needed. This…...