4+ hour, 43+ min ago   (379+ words) An new end-to-end nomination workflow improves the nomination of genomic sites that may be unintentionally edited by CRISPR-Cas, combining high analytical sensitivity with a comparatively manageable list of candidates for confirmation. Tests in cell lines and human HSPCs suggest clinical…...

1+ mon, 4+ day ago   (335+ words) A new artificial intelligence–guided strategy can design highly divergent yet functional variants of TnpB, a compact RNA-guided nuclease that is evolutionarily related to CRISPR-Cas12 enzymes. By combining a structure-based inverse protein-folding model with evolutionary constraints, they generated synthetic nucleases…...

2+ mon, 1+ week ago   (185+ words) Peer reviewed studies include: NEW YORK--(BUSINESS WIRE)--Dante Labs enabled more than 100 global scientific studies on rare diseases, transcriptomics, CRISPR gene editing ancient DNA samples and oncology. Dante Labs also published its own papers on peer reviewed journals, including…...