A 12-run Plackett–Burman screening identified agitation speed, sodium nitrate, magnesium sulphate and carbon source as the dominant factors raising extracellular protease production by Bacillus sp. MTCC 511 up to 20.6-fold under mutagenic stress.
Combinatorial biosynthesis in Magnaporthe grisea shows that cytochalasan P450 enzymes tolerate macrocycle size differences but are restricted by the stereochemistry of methyl groups around the backbone.
Generation Got Conversational. Interpretation Is Still 2D. Ars Technica reported this week... Tagged with science, biotech, ai, software. #generation-got-conversational-interpretation-is-still-2d Generation Got Conversational. Interpretation Is Still 2D. For structural biologists, that raises an immediate question. If generation becomes conversational, how do we keep…
The grant funds the next chapter for Caravel's full-stack platform—built to create value for all proteins—while scaling machine learning datasets and real-world pilots for existing customers. Michał Jastrzębski also joins as CTO to lead the company's AI-driven protein…
Protein design (or protein engineering) is a technique by which proteins with enhanced or novel functional properties are created. Proteins can be engineered by rational design, which typically uses computational tools to identify useful mutations, or by directed evolution, which…
Proving that function survives Another AI leader needs binding data “Adaptyv’s role is to turn AI-designed proteins into real experimental data, quickly and at scale,” said Julian Englert, CEO and co-founder of Adaptyv Bio. “We use Carterra’s HT-SPR for campaigns…
Milder conditions, less energy consumption and waste The weak spot of enzyme biocatalysis is the low stability of some enzymes. "Since the enzyme often has to be replaced in such cases -- which is expensive -- it is extremely important to increase…
SAN DIEGO, Oct. 17, 2017 /PRNewswire/ -- Forge Therapeutics, Inc. (Forge) announced today that the companies have expanded their existing strategic alliance and launched the BLACKSMITH platform to... SAN DIEGO, Oct. 17, 2017 /PRNewswire/ -- Forge Therapeutics, Inc. (Forge) announced today that the companies have expanded…
A synthetic eight-residue peptide modeled on the cobalt nitrile hydratase metal-binding motif binds Co(II) in two distinct coordination states and undergoes coupled metal and cysteine oxidation upon exposure to dioxygen.
A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from mining candidate enzymes in massive sequence databases to generating new variants…
AI for proteins: AlphaFold and its successors, de novo protein design, and AI-designed enzymes, antibodies and binders.
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