A mouse study identifies the mitochondrial enzyme CMPK2 as a key mediator of doxorubicin heart injury and reports that flavin adenine dinucleotide blocked the pathway without reducing antitumor efficacy. CMPK2–mtDNA Axis Drives Doxorubicin Heart Damage, Study Finds Subject of Research: The…
A pacing outcome predictor applied to personalized cardiac digital twins separated all 10 patients with repaired Tetralogy of Fallot by clinically inducible ventricular tachycardia in a retrospective study. Because the study is retrospective and involves only 10 patients, the findings should be…
A time-resolved proteomic study in mice shows that loss of the desmosomal protein plakophilin-2 triggers right-ventricle-led molecular remodeling, with early mitochondrial alterations that honokiol treatment broadly attenuated.
A case report describes how echocardiography and cardiac magnetic resonance together diagnosed arrhythmogenic cardiomyopathy with multiple right-ventricular apical thrombi in a 37-year-old woman, whose thrombi resolved after anticoagulation. News Source: Ophelia Keating. (October 29, 2026). Imaging Teamwork Caught Rare Right-Ventricular Thrombi in…
An analysis of genetic data from more than 13,500 participants in the ASPREE clinical trial showed that low-dose aspirin may be associated with an approximately 70% reduction in the relative risk of dementia in older people with a specific genetic profile. At…
Heart muscle cells grown from lung cancer patients reproduce individual susceptibility to osimertinib-induced cardiac dysfunction, with impaired AMPK–LKB1 signaling marking vulnerable donors and metformin cotreatment protecting the susceptible cells in vitro.
A long-running debate over how an important gene-silencing protein identifies its targets has been resolved by researchers at Massachusetts General Hospital (MGH). Their findings, reported in Nature Structural and Molecular Biology, also explain certain mysteries about the behavior of this…
A pooled analysis of 1924 tafamidis-treated patients found women made up 11.1 percent of the cohort, more often carried hereditary TTR variants, and appeared more symptomatic at presentation, while men had a higher adjusted risk of all-cause mortality.
Results indicated that people in the highest quintile of both genetic and socioeconomic risk had a more than seven-fold higher prevalence of type 2 diabetes (22.2% vs. 3.1%) and a more than three-fold higher prevalence of obesity (69.0% vs. 20.9%) compared with those in the…
A new review maps how oxidative stress and inflammation drive diabetic nephropathy and highlights biomarkers and drugs for earlier detection and treatment.
Cardiovascular biology: heart muscle and blood vessels, cholesterol and lipid genetics such as PCSK9 and Lp(a), and heart regeneration research.
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