Scientists have discovered that amyloid fibers in semen can carry RNA into sperm and deliver it to embryos. Prepare for a crazy medical crossover episode. A discovery about how HIV infects cells has led to a bizarre secret about sperm…
A large-scale international study, led by Ole Andreassen at University of Oslo and Oslo University Hospital, in collaboration with international consortium, offers new insights for understanding the disease and developing future treatments. Large genetic study uncovers new risk factors for…
Neuroscientists from Johns Hopkins Medicine say they have determined how a brain cell surface molecule shapes the way certain neurons behave. "We've discovered that the calcium permeable subtype of AMPA receptors has an added role of suppressing the selectivity of…
A University of Minnesota Twin Cities researcher is part of an international team that has used imaging technology to show, for the first time, the creation and elimination of synapses between neurons in the brains of live mice. The research…
The study does not prove that advanced biological age causes dementia; it only shows an association. "With the rising impact of dementia around the world, identifying risk factors and implementing preventive measures is essential," said study author Yacong Bo, PhD,…
Restricted Flow. The width (red bar) of a rat cortical capillary (left) shrinks in the vicinity of a pericyte (white arrowheads) after addition of Aβ (right). [Courtesy of Nortley et al., Science/AAAS.] The authors made similar observations in APPNL-G-F…
A viral gene therapy that ablates the cerebrospinal fluid-producing choroid plexus prevented hydrocephalus-related brain swelling in mice while moderately reducing hippocampal neurogenesis. Choroid Plexus Ablation Eases Hydrocephalus Brain Swelling in Mice Subject of Research: Choroid plexus ablation via AAV5 gene therapy…
The health impacts of a complex protein that plays a major role in the development of Alzheimer's disease and heart conditions can be lessened by three kinds of drug inhibitors, according to scientists at the University of Colorado Anschutz Medical…
CREB binds to a cAMP response element (CRE) in the promoter region of its target genes. Assembly and disassembly of CREB-CRE interactions control spatiotemporal gene expression in the nucleus. However, how CREB interacts with CRE in activity-dependent mechanisms is not…
Scientists know that the ravages of Alzheimer disease cripple the ability to lay down new memories, but the precise molecular dance that determines the success or failure of memory formation is still... Scientists know that the ravages of Alzheimer disease…
The biology of neurodegenerative and neurological disease: Alzheimer's, Parkinson's, ALS, Huntington's and other disorders of the brain and nerves.
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