The team profiled more than 600,000 cells from across the fish to build the whole-body single-cell transcriptome atlas of which genes are active in which cell. A cell’s transcriptome is the full set of RNA molecules it has made from its…
Developmental tracing in mice shows the TMJ disc forms independently of the condyle with a tendon-like molecular signature, supporting its evolutionary origin from a trapped tendon.
Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state in vitro, with the effect reversible on drug withdrawal. Subject of Research: Inhibition of the epigenetic enzyme PRMT5 to maintain undifferentiated spermatogonial stem…
Development, Genes and Evolution, one of the oldest journals in developmental biology, has published its last issue under its current name. In a farewell editorial, Editor-in-Chief Angelika Stollewerk announced that she is stepping down at the end of 2024 and that…
A novel homozygous frameshift mutation in CFAP65 was identified in two infertile brothers from a consanguineous Pakistani family with severe sperm flagella abnormalities. Subject of Research: Genetic basis of multiple morphological abnormalities of sperm flagella in male infertility Article Title: A…
A new study maps about 1,100 sites where PRC2 rapidly re-establishes itself in mouse embryonic stem cells after reversible depletion of the core subunit Suz12.
For decades, scientists have been able to look at individual moments in the development of an embryo: a snapshot of a developing brain, a picture of how the heart takes shape, or a glimpse of cells beginning to form the…
For decades, scientists have been able to look at individual moments in the development of an embryo: a snapshot of a developing brain, a picture of how the heart takes shape, or a glimpse of cells beginning to form the…
Mouse embryos exposed to oxidative damage during in vitro fertilization can stall at the two-cell stage, and a new study points to a specific epigenetic culprit: the chromatin protein HP1α. Researchers report that oxidative damage increases HP1α, which suppresses the totipotency marker…
In neurobiology, amyloid proteins are notorious as the pathological hallmarks of debilitating neurodegenerative disorders, aggregating into neurotoxic plaques and tangles that destroy synapses in Alzheimer’s, Parkinson’s, and related dementias. Yet across the human body, functional amyloids perform diverse, non-pathological tasks…
How a single cell becomes a body: embryos and organ development, stem cell science, regeneration and the biology of reproduction.
An article joins this feed when it matches these terms. Each one is also a search of its own.