Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a promising new strategy to make cancer-fighting immune cells stronger and potentially longer-lasting, a discovery that could help improve the effectiveness of immunotherapies that use a patient's own immune…
A previously unknown mechanism helps cancer cells selectively produce proteins that drive tumor growth - such as KRAS - in common cancers, according to new research from The University of Texas MD Anderson Cancer Center. The findings reveal that targeting a specific…
(L to R) Qianqian Li, PhD; Dana Farmer, PhD; first author Justin Williams, PhD; corresponding author Martine Roussel, PhD, all of St. Jude Department of Tumor Cell Biology, and Jake Friske, PhD, St. Jude Graduate School of Biomedical Sciences Pediatric brain…
Complexity of pancreatic cancer reproduced in the laboratory The team used machine learning to categorize the newly grown organoids based on their morphologies in defined groups for further systematic analyses. "We identified different phenotypes within the two subtypes epithelial and…
At the same time, antibody based therapies— despite their success in peripheral tumors— largely fail to access the brain parenchyma at therapeutically relevant levels. This disconnect has driven an urgent need for new BBB transport routes that are both selective…
A central finding concerns the malignant cells themselves. The team subdivided them into three distinct subclusters, each carrying its own unique transcriptional program. Pseudotime trajectory analysis suggested a developmental hierarchy among these malignant populations, a structure supported by the dynamic…
A-gyo and UN-gyo achieved 100% complete tumor regression in animal models of human colorectal, ovarian, and pancreatic cancer, with no observable systemic toxicity. A remarkable study published in Nature Biomedical Engineering reports 100% complete tumor regression in mouse models of human colorectal,…
Findings highlight the value of broad structural profiling when targeted testing leaves important questions unresolved The study evaluated the same proprietary Hi-C sequencing approach used in Aventa™ Lymphoma, Arima's clinical test for fusion and rearrangement detection in B- and T-cell…
This retrospective study evaluated the impact of a pre-emptive rituximab (RTX) strategy for EpsteinâBarr virus (EBV) reactivation on immune recovery and outcomes of 219 high-risk recipients undergoing allogeneic stem cell transplantation (allo-SCT)... Thank you for visiting nature.com. You are…
A new Cell Division study reports that cadherin genes CDH1, CDH2, and CDH3 are upregulated in nasopharyngeal carcinoma cell lines and tumor databases, and that silencing them curbs cancer cell growth and migration, with possible links to WNT signaling. Article Title: Role of…
The biology of cancer: how tumours start and spread, cancer genomes and targeted drugs, and immunotherapies that turn the immune system on cancer.
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