Nanoscale vesicle-like particles isolated from the medicinal herb Selaginella doederleinii suppressed liver cancer cells and tumors in mice by inducing ferroptosis through the xCT/GPX4 axis, according to a new preclinical study. News Source: Nathaniel Bowman. (October 29, 2026). Plant-Derived Nanoparticles From a…
Newswise — Researchers at the University of Eastern Finland have identified a transporter protein with the potential to open new avenues for improving creatine delivery into the brain and for developing other therapies targeting the central nervous system. The implications of…
Researchers found inspiration in the microhooks of parasites, barbed stingers of honeybees, and scaled quills of porcupines to create 4D-microneedle arrays that could end the need for painful hypodermic needles.(Credit: Getty Images) New 4D printed microneedles could one day eliminate…
The study built on the group’s previously published human primary cell-based BBB model. Barrier integrity in the current experiments was confirmed using transepithelial electrical resistance (TEER) measurements and FITC-dextran permeability assays, ensuring that observed drug movement reflected a functioning barrier…
Researchers at the University of Eastern Finland have identified a transporter protein with the potential to open new avenues for improving creatine delivery into the brain and for developing other therapies targeting the central nervous system. Novel transporter protein discovery…
A new mini-review details how hybrid and synthetic extracellular vesicle platforms are being engineered to overcome the low yield, heterogeneity, and limited controllability of natural vesicles for drug delivery and theranostics. Subject of Research: Engineering of hybrid and synthetic extracellular…
In experiments using animal models with femoral bone defects, the hydrogel was successfully injected, adhered accurately, and effectively delivered components essential for bone regeneration. Professor Cha commented, "The injectable hydrogel system for bone regeneration developed by our research team represents…
A new review finds edible source-derived exosome-like nanoparticles show preclinical promise against hepatocellular carcinoma, but clinical translation faces major hurdles. Exosome-like nanoparticles harvested from edible and medicinal sources, including medicinal plants and mammalian milk, are emerging as a promising but…
A new review outlines how engineered exosome nanocarriers could deliver drugs precisely to diseased heart tissue, while major manufacturing and regulatory hurdles remain before human use.
A mini-review outlines how formulation science and device technologies are overcoming delivery barriers for large molecule therapeutics. Subject of Research: Advances and challenges in delivery technologies for large molecule therapeutics Article Title: Advancements and challenges in large molecule drug delivery…
Getting drugs where they are needed: nanoparticles and lipid nanoparticles, microneedles, targeted delivery and crossing the blood-brain barrier.
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