A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's disease.
A new rat study shows that an image-derived input function with population-based metabolite correction can quantify the synaptic vesicle tracer [18F]SynVesT-1 non-invasively, closely tracking arterial blood-based measurements.
A new letter to the editor argues that a rat model of direct platinum coil brain contact is a deliberate worst-case exposure paradigm whose findings should not be read as evidence of clinical safety.
A new review maps how intercellular mitochondrial transfer and transplantation could treat central nervous system disorders, while flagging dye-labeling artifacts and scarce functional validation as key obstacles. The authors focus on what triggers mitochondrial transfer, the direction it takes, the…
A new Nature Chemical Biology study identifies the NAD+ catabolite ADP-ribose as an inducer of neuronal ferroptosis through inhibition of the nucleoside transporter ENT2.
To elucidate the functional relevance of the astrocyte network, the researchers generated a mouse model in which the two key connexins responsible for linking astrocytes together can be selectively inactivated. Once the corresponding genes were turned off, the astrocytes lost…
In a mouse model of multiple system atrophy, oligodendroglial alpha-synuclein drives early ventral midbrain transcriptional changes in mitochondrial, metabolic and myelin programs before overt neuronal loss, with cerebellar counterparts emerging later. The team performed bulk RNA sequencing of ventral midbrain…
A new review in Nature Reviews Neurology outlines how mitochondrial biomarkers spanning fluid, genetic, multi-omics and imaging domains could aid diagnosis and monitoring across neurological diseases, while cautioning that clinical implementation remains limited. Mitochondrial dysfunction is increasingly recognized as a…
A non-electrophilic TRPA1 modulator, MNP-021, demonstrated the ability to protect neuronal and glial functions from glucotoxicity and neuroinflammation associated with diabetes. Subject of Research: The neuroprotective effects of the TRPA1 modulator MNP-021 against diabetes-related metabolic and inflammatory stress in neuronal and glial…
GENFI Top Hits. CSF proteomics linked abundance of CALB2, GRN/NAGA, and PEA15/SEMA6A to C9ORF72 (gold), GRN (red), and MAPT (blue) forms of FTD, respectively. Solid circles indicate statistical significance. [Courtesy of Sogorb-Esteve et al., Science Translational Medicine/AAAS.] GENFI had previously analyzed…
Parkinson's disease biology: alpha-synuclein, dopamine neurons, genetics such as LRRK2 and GBA, early detection and new therapies.
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