Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state in vitro, with the effect reversible on drug withdrawal. Subject of Research: Inhibition of the epigenetic enzyme PRMT5 to maintain undifferentiated spermatogonial stem…
A novel homozygous frameshift mutation in CFAP65 was identified in two infertile brothers from a consanguineous Pakistani family with severe sperm flagella abnormalities. Subject of Research: Genetic basis of multiple morphological abnormalities of sperm flagella in male infertility Article Title: A…
In neurobiology, amyloid proteins are notorious as the pathological hallmarks of debilitating neurodegenerative disorders, aggregating into neurotoxic plaques and tangles that destroy synapses in Alzheimer’s, Parkinson’s, and related dementias. Yet across the human body, functional amyloids perform diverse, non-pathological tasks…
It may soon be possible to coax human skin cells into becoming functional eggs and sperm using a technique known as “in vitro gametogenesis”. This involves the creation (genesis) of eggs and sperm (gametes) outside the human body (in vitro).
Lab-grown blood-brain barrier cells from adults with ADHD carrying PARK2 copy number variations show small genotype-linked changes, while culture duration drives broad metabolic remodeling. Subject of Research: Blood-brain barrier models derived from stem cells of adults with ADHD and PARK2 copy number…
This week, Louise Brown, the first person born after conception by in vitro fertilization (IVF), celebrates her 40th birthday. Thanks to assisted reproductive technologies like IVF and intracytoplasmic sperm injection and to new techniques developed in laboratory animals, researchers are able…
A narrative review proposes that mitochondrial injury links varicocele-related oxidative stress and sterile inflammation, while stressing that the full pathway has not been causally demonstrated in human patients.
A longstanding mystery about the genetic messages carried by sperm led researchers to investigate an unexpected component of seminal fluid and its possible role in early embryonic development. Study: Amyloid-mediated RNA uptake by sperm for embryonic delivery. Image Credit: Anusorn…
A PLOS Genetics review argues that low recombination near centromeres may explain extensive sex-linked regions without invoking active recombination suppression. Subject of Research: The role of pericentromeric genome regions and the centromere effect in sex chromosome evolution Article Title: The…
A survey of 19 natural populations reveals that the midge Chironomus agilis, long considered chromosomally uniform, harbors substantial inversion polymorphism, especially in Western Siberia.
The biology of reproduction: sperm and eggs, fertilization, the placenta and pregnancy, fertility science and the lab advances behind IVF.
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