An 11-protein signature from circulating extracellular vesicles, validated in an independent cohort, was associated with advanced fibrosis in MASH and improved model discrimination over clinical variables alone.
Waiting times for an initial neurology appointment for memory concerns average more than 4 months, potentially delaying diagnosis and treatment. In a nationwide telephone survey of 150 neurology clinics nationwide, researchers found that wait times averaged 21.1 weeks at specialized centers and 15.6 weeks…
This symposium will feature three analyses from CELIA, including 96-week long-term extension efficacy and safety data, additional 76-week tau biomarker and amyloid PET data, and 76-week item analyses and select subgroup efficacy data. These data build on previously reported CELIA…
Aspirin reduces dementia risk 3.5-fold in high platelet polygenic score carriers while raising bleeding risk. Read more here. This site is intended for healthcare professionals Aspirin Lowers Dementia Risk in High Platelet Genetic Group - High platelet polygenic scores link daily…
A modified algorithm using a high-sensitivity cardiac troponin T (hs-cTnT) assay safely and rapidly ruled out more patients with myocardial infarction in one US emergency department, with more than half of patients ruled out 1 hour after presentation, when compared with…
However, fewer than 5% of all in vitro diagnostics are companion diagnostics. And, most are used in oncology. Specifically, 30 companion diagnostics are officially designated by FDA as required for the use of 25 drugs in at least one indication. Twenty out of…
A toxic union for neurons Given these results, the researchers designed an innovative strategy to trick the Poly-GR dipeptides and reduce their toxicity. They created a trap, a molecule that mimicked the specific rRNA sequence to which Poly-GR dipeptides bin…
In amyotrophic lateral sclerosis (ALS), motor neurons in the spinal cord and central nervous system die off for unknown reasons, causing creeping paralysis and, eventually, death. Mutations in the... In amyotrophic lateral sclerosis (ALS), motor neurons in the spinal cord…
In SOD1G85R mice, sciatic nerve inoculation with two distinct SOD1 aggregate strains transmitted templated aggregation to the CNS, with strain A causing earlier disease onset and end-stage disease than strain B.
The Alzheimer's Drug Discovery Foundation's (ADDF) Diagnostics Accelerator (DxA) announces a new collaboration with Eli Lilly and Company, which has licensed the ADDF's SpeechDx dataset, the world's largest harmonized longitudinal dataset of speech and biomarker data spanning the Alzheimer's continuum,…
Biomarker discovery and new blood tests: Alzheimer's blood tests such as p-tau217, proteomic and metabolic markers, and AI reading molecular data.
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