A novel antibody therapy has strengthened the immune system’s ability to fight cancer in mice by targeting immune-suppressing cells more precisely than previous approaches, according to new research. The treatment, developed by Baomei Wang and colleagues at Genentech, targeted regulatory…
A new review of primary biliary cholangitis (PBC) has highlighted how interactions between immune cells and bile duct cells drive chronic inflammation, potentially leading to more personalised treatments. PBC is a chronic autoimmune disease that destroys small bile ducts inside…
Removing SRC-3 from regulatory T cells reduced tumour immunosuppression in preclinical models, allowing cytotoxic T cells and natural killer cells to infiltrate tumours. Dr David Lonard and Dr Sonal Gupta discuss how altering Treg activity could restore anti-tumour immunity. Regulatory…
Sponsored by Miltenyi Biotec Follow a complete high-plex spatial proteomics workflow on archival FFPE tumour tissue, from marker-panel design to cell phenotyping, with a prostate cancer case study from the University of Surrey. In this webinar, Dr Nicola Annels and…
Drug Discovery News A wider view of neuronal activity in brain organoids Discover how researchers are looking beyond individual neurons to understand how genetic variations shape activity across brain organoid networks. Many genetic variants have been linked to psychiatric disorders,…
BioWorld News Biotech investors reload as China innovation drives new capital cycle
MSA and Parkinson’s share alpha-synuclein pathology but progress very differently. Earlier detection could help researchers understand why – and reveal which proteins, cells and disease mechanisms offer the strongest therapeutic targets. Source: Alpha Tauri 3D Graphics / Shutterstock Alpha-synuclein is a protein found…
The right signals can make or break an organoid model. From growth and differentiation to downstream drug testing, cytokines and growth factors are critical to creating cultures researchers can rely on. Figure 1. Key signalling pathways and representative cytokines and growth…
Scientists at Memorial Sloan Kettering Cancer Center have identified DHRS7 as the gene encoding a long-elusive enzyme in the 5-oxoETE inflammatory signalling pathway, uncovering an unexpected protective function. Researchers have uncovered a dual role for the 5-oxoETE signalling pathway, which helps…
Scientists at Moderna Inc. are seeking a solution to the rapid emergence of viral variants that escape treatments. Many monoclonal antibodies (mAbs) initially work well against a single target but lose efficacy as viruses such as SARS-CoV-2 accumulate mutations. To…
Finding new drug targets and molecules: target discovery, screening, small molecules, protein degraders and molecular glues.
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