Combinatorial biosynthesis in Magnaporthe grisea shows that cytochalasan P450 enzymes tolerate macrocycle size differences but are restricted by the stereochemistry of methyl groups around the backbone.
The second installment is about synthetic resins and cellulose. Long time no see, everyone. I would like to talk about another interesting science topic. This time, it is about chemical substances called synthetic resins and cellulose. At first glance, these…
Study explored how restricting the amino acid diversity in ancestral enzymes can uncover alternative catalytic functions, including ATP formation from ADP Overall, the study shows that restricting amino acid diversity can reveal catalytic capabilities beyond a protein’s conventional function. By…
These monooxygenases depend on partner proteins that shuttle electrons from nicotinamide cofactors into the P450 active site. The structural comparison produced a surprise. Although the M. maydis enzyme, UmaCPR, shares greater sequence similarity with ascomycete CPRs, which include the Candida enzyme, its…
A new review synthesizes global advances in sustainable Ulva biomass production, spanning physiology, genomics, seedling technology and farming systems.
Milder conditions, less energy consumption and waste The weak spot of enzyme biocatalysis is the low stability of some enzymes. "Since the enzyme often has to be replaced in such cases -- which is expensive -- it is extremely important to increase…
This paper reviews amino acid fragmentation under hydrothermal and pyrolytic conditions, highlighting deamination and decarboxylation as key reactions where structural differences dictate degradation pathways, and explores production methods like microbial fermentation and catalytic synthesis from nitrogen-rich biomass. Degradation Pathways of…
Engineers boosted a GH5 endoglucanase's catalytic efficiency up to 2.73-fold by mutating solvent-exposed peripheral residues to loosen the catalytic cavity, though the gains came with reduced thermal stability. Subject of Research: Protein engineering of the peripheral regions of a GH5 endoglucanase to…
The enzymes found in living organisms have impressive catalytic power. Thanks to enzymes the chemical reactions that sustain life happen millions of times faster than they would occur without them. Enzymes speed up reactions by helping to lower the activation…
Researchers engineered aldehyde dehydrogenases into oxidative ester synthases whose regioselectivity for primary or secondary alcohols is controlled by imidazole acting as an allosteric molecular switch. Chemists have long struggled to attach ester bonds to exactly the right spot on a…
Fuels, chemicals and materials made by biology: engineered microbes and algae for fuels, bio-based plastics and spider silk, and biorefineries.
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