VideoA funny-sounding bacteria that you’ve never heard of—Wolbachia—will likely be an important weapon in the fight against Zika, dengue and other viruses plaguing the tropics. These arbovirus infections have been exploding in Latin America and the Caribbean and…
A purely computational study screened 407,270 natural compounds against the dengue virus RNA-dependent RNA polymerase and identified four candidates with predicted binding stronger than a reference inhibitor, pending experimental validation. Subject of Research: Computational identification of natural product inhibitors of the…
A retrospective study of 425 patients in China found metagenomic next-generation sequencing detected tuberculosis with 90.1% sensitivity, outperforming six routine diagnostic tests. News Source: Ophelia Keating. (October 29, 2026). Rapid Sequencing Outperforms Routine Tests in Detecting Tuberculosis, Study Finds. Scienmag.
A trial-based economic evaluation found siltartoxatug achieved far higher trial-defined antibody response rates than human tetanus immunoglobulin in Chinese adults for an incremental drug cost of CNY 58.42 per patient. News Source: Ophelia Keating. (October 29, 2026). New Tetanus Antibody Beats Standard Treatment…
A computational study has designed a multi-epitope tuberculosis vaccine candidate from conserved immunoreactive peptides, fused to a non-toxic enterotoxin fragment to target mucosal immunity.
The gene is responsible for males being drawn to the sound of the wingbeat of females. Mutating this gene, known as the fruitless gene, in males makes them incapable of locating female mosquitoes to mate, according to the team, comprising…
The assay targets a diagnostic single-nucleotide polymorphism within the Internal Transcribed Spacer 2 (ITS2) region of ribosomal DNA. According to the authors, Mohamed Kader Haidara, Gleb N. Artemov and Igor V. Sharakhov, the method was designed to be rapid, sensitive, specific and suitable for…
A new study reports that soluble CD161 is elevated in tuberculosis patients, especially those with radiographically severe disease, and that blocking the CD161–LLT1 interaction alters cytokine secretion in antigen-stimulated cells. Beyond the blood measurements, the team examined CD161 distribution in lung and lymph-node…
Researchers detected DNA copies of the dengue virus genome in mosquito cells and wild Aedes albopictus, and recovered one host-virus chimeric sequence suggesting rare genomic integration. Subject of Research: Formation of dengue virus serotype 1 DNA fragments and a host-virus chimeric…
A new study reports that the kinase CK2α regulates P-glycoprotein expression in macrophages through two signaling pathways, and that combining a CK2 inhibitor with rifampin reduced bacterial burden in tuberculosis-infected mice.
Malaria, tuberculosis, dengue, Chagas and other parasitic and tropical diseases: the pathogens behind them and new vaccines and drugs.
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