Metabolic theory for brain wiring at different temperatures The research was financed by the German Research Foundation (DFG) through the Research Unit RobustCircuit -- From Imprecision to Robustness in Neural Circuit Assembly (FOR 5289) and the Institute for Quantitative and Computational Biosciences…
A University of Minnesota Twin Cities researcher is part of an international team that has used imaging technology to show, for the first time, the creation and elimination of synapses between neurons in the brains of live mice. The research…
Newswise — LOS ANGELES (Oct. 27, 2026) -- A walnut-sized area of the brain known as the amygdala plays a giant role in determining which experiences end up in long-term memory and which are forgotten. The Cedars-Sinai Health Sciences University discovery points to the…
Human brain recordings reveal how category-selective amygdala neurons predict later image recognition, beyond emotional content. (CREDIT: The Brighter Side of News) Whether a new image becomes a memory may depend partly on how strongly a particular group of brain cells…
A viral gene therapy that ablates the cerebrospinal fluid-producing choroid plexus prevented hydrocephalus-related brain swelling in mice while moderately reducing hippocampal neurogenesis. Choroid Plexus Ablation Eases Hydrocephalus Brain Swelling in Mice Subject of Research: Choroid plexus ablation via AAV5 gene therapy…
Patient-derived ventral organoids show that GATOR1-related focal epilepsy involves MAFB-driven interneuron defects independent of mTOR hyperactivation. Using patient-derived brain organoids, researchers have uncovered how mutations in GATOR1 genesâthe most common monogenic cause of non-acquired focal epilepsyâdisrupt brain development in…
Restoring the peroxisomal fission protein PEX11β improved motor and cognitive deficits and mitochondrial gene expression in a toxin-induced mouse model of Huntington's-like disease, with Yin Yang 1 identified as a key regulator of PEX11β and Complex II co-expression. In a study published in…
A simulation-based study presents a nonlinear state-space model linking stress, negative cognitive bias and multivariate EEG and ERP signals, reporting model-implied slopes and sensitivity checks rather than clinical effects. The work, authored by Yimin Zhang and Jianping Liu of Jiangxi…
The tool could eventually lead to an entirely new approach for treating mental health By Simon Makin edited by Allison Parshall The human brain holds around 86 billion neurons, wired together in a vast web of hundreds of trillions of connections.
CREB binds to a cAMP response element (CRE) in the promoter region of its target genes. Assembly and disassembly of CREB-CRE interactions control spatiotemporal gene expression in the nucleus. However, how CREB interacts with CRE in activity-dependent mechanisms is not…
How the brain is wired: neurons, synapses and glia, neural circuits, neurotransmitters, and the projects mapping brains and connectomes.
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