A VetCompass study of 28,032 UK Yorkshire Terriers found declining ownership, high longevity of 13.56 years at death, and periodontal disease as the most common disorder.
A systematic analysis of hundreds of WGBS datasets finds that apparent mitochondrial DNA methylation is driven mainly by technical artifacts, particularly missing DNA fragmentation and incomplete bisulfite conversion. Article Title: Apparent methylation of mitochondrial DNA in WGBS is dominated by…
The survey responses showed that the majority of the dogs, 75.8 percent (485 of 640), exercised for one to three hours each day. Intense exercise accounted for less than two hours per day for most dogs, with 88.7 percent falling into this category, indicating…
A UK cohort study of over 2.25 million dogs found giant breeds had a 73.8 percent annual disorder rate and a median lifespan of 8.94 years, about 25 percent shorter than dogs overall.
A new review synthesizes evidence that metabolic stress may shape DNA methylation through methyl-donor availability, impaired demethylation, and chromatin changes across multiple organs.
The results showed a clear negative relationship. Mean log-sVeDBA declined with increasing body mass, with an estimated scaling exponent of −1.37 and a 95% confidence interval spanning −2.33 to −0.41. The model’s R-squared value was 0.175, indicating that body mass explained a modest but detectable…
Heart muscle cells grown from lung cancer patients reproduce individual susceptibility to osimertinib-induced cardiac dysfunction, with impaired AMPK–LKB1 signaling marking vulnerable donors and metformin cotreatment protecting the susceptible cells in vitro.
Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state in vitro, with the effect reversible on drug withdrawal. Subject of Research: Inhibition of the epigenetic enzyme PRMT5 to maintain undifferentiated spermatogonial stem…
A new review in Clinical Epigenetics distinguishes epigenetic changes proven to persist after glycemic normalization in diabetic cardiomyopathy from those whose persistence remains unverified.
"This creates a paradox called 'missing regulation'," says Xiang. "We decided to look at this problem to see how much variation in cattle traits can be explained by mutations changing gene expression or RNA splicing." The researchers found that regulatory…
How genes are switched on and off: epigenetics, DNA methylation, chromatin and gene expression, and epigenetic clocks as biology.
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