Immune cells, pictured here in bright teal, occupy the epithelial layers between the skin surface and its stem cells and act as a system regulator. (Credit: Fuchs lab) "Essentially, Langerhans cells act as liaisons to regulate host-microbe interactions, while joining…
Decidual macrophages (dMÏ) contribute to maternalâfetal tolerance. However, the mechanism of dMÏ differentiation during pregnancy is still largely unknown. Here, we report that receptor activator for nuclear factor-κB ligand (RANKL), secreted by... Uncover the latest and most impactful research…
Simon Conway working in his lab. Newswise — Scientists at the Indiana University School of Medicine have gained new insights into Barth syndrome, a rare genetic disorder that primarily affects males. In this study, researchers found that the mouse models had…
A cross-sectional study of 100 Algerian dromedary camels reports that dehydration is associated with a thinner splenic marginal zone and reduced B-cell density. Dehydration thins the spleen's immune hub in desert camels Subject of Research: Dehydration-associated remodeling of the splenic marginal…
Corresponding author Yongqiang Feng, PhD, St. Jude Department of Immunology. “We found that under normal conditions, the COMPASS pathway enables regulatory T cells to prevent inflammation and autoimmunity in the intestine,” said corresponding author Yongqiang Feng, PhD, St. Jude Department…
A microscopic image of an intestinal organoid in which the nuclei of the cells are blue, epithelial cells are white, T cells are green and other immune cells are red.Antonio Santos Autoimmune Conditions July 24, 2024 Balls of intestinal cells from…
Immunotherapy is effective only for a small proportion of patients Using human blood, the scientists extracted monocytes which they transformed into a large variety of antigen-presenting cells and analyzed using state-of-the-art methods. What is the activity of different genes of…
"'How could this work?' we asked ourselves," said Caspi. "Scientists are like little kids, when they get an answer to one question, there is immediately the next level of 'why?' So we started looking at the deeper mechanisms that make…
Trillions of bacteria live in the human gut without triggering an immune response. Scientists at St. Jude Children's Research Hospital have now discovered a gene-regulatory pathway that helps maintain this delicate balance. COMPASS pathway helps regulatory T cells prevent intestinal…
A new study shows that PKC signalling, acting through FAK, PI3K/AKT and the transcription factors NF-κB and PPARG, drives monocytes into a lipid-associated macrophage-like state that mirrors disease tissue in mice. Scientists map the signals that turn monocytes into lipid-handling…
Immune science: T cells, B cells and antibodies, innate immunity, regulatory T cells and immune tolerance, immune memory and inflammation as biology.
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