A-gyo and UN-gyo achieved 100% complete tumor regression in animal models of human colorectal, ovarian, and pancreatic cancer, with no observable systemic toxicity. A remarkable study published in Nature Biomedical Engineering reports 100% complete tumor regression in mouse models of human colorectal,…
Whole-genome sequencing of 23 clinical isolates from China shows that 16S rRNA sequencing misidentifies Nocardia gipuzkoensis as N. abscessus, with highest susceptibility to trimethoprim–sulfamethoxazole, linezolid, and amikacin. The team examined 23 strains of N. gipuzkoensis isolated from clinical cases in China between 2017 and…
A bait-capture method sequences Cryptosporidium genomes from as few as 25 oocysts in stool, revealing host-adapted lineages. Cryptosporidium, a parasite that causes diarrhea and high mortality in young children in Africa and southern Asia, has long been difficult to study genetically…
Metagenomic sequencing of Chinese pig samples reconstructed nine genomes of Lawsonia intracellularis, revealing 26.38 percent PCR positivity, exceptional genomic conservation and field strains divergent from the vaccine. News Source: Kristina Jarvis. (October 29, 2026). Metagenomics Tracks China’s Unculturable Pig Pathogen Across Global Strains.
A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's disease.
A new review of primary biliary cholangitis (PBC) has highlighted how interactions between immune cells and bile duct cells drive chronic inflammation, potentially leading to more personalised treatments. PBC is a chronic autoimmune disease that destroys small bile ducts inside…
A laboratory study of Ruminococcus albus 7 with four Methanobrevibacter strains reveals partner-specific shifts in hydrogen metabolism, biofilm genes and sulfur amino acid exchange during syntrophic growth. Scientists have mapped in fine detail how a dominant rumen bacterium and four methanogen…
A computational survey of 381 oral bacterial genomes found 48,234 G-quadruplex motifs, with a 2.5 to 3-fold enrichment in promoter regions and rapid evolutionary turnover among related species. Subject of Research: Computational mapping of G-quadruplex DNA motifs across oral bacterial genomes and their…
The “dual-mechanism” anti-IgE antibody CUE-221 has delivered encouraging phase 2 results in chronic spontaneous urticaria. Could it separate from omalizumab and ozureprubart in food allergy? Kuo et al. proposed the CD23 mechanism on the basis of data showing that UB-221, as CUE…
The Age of MicrobesSteven D. AllisonHarvard University Press Out 3 November (US) and 27 November (UK) It’s 2030. Heatwaves are scorching parts of the globe, while elsewhere, hailstorms or tsunamis ravage homes, cities and farmlands. Wildfires rage across continents, Arctic ice sheets dwindle, volcanoes…
Microbiome research: the gut, skin, oral and soil microbiomes and how microbes shape health, development and the brain.
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