As the globe faces a rise in antibiotic-resistant bacteria – making traditional antibiotics ineffective – specific viruses could offer a solution. Viruses called bacteriophages, or phages, target bacteria but can’t infect humans or other higher organisms. Phages inject their DNA into the…
Built by the team behind Evo and Evo 2, Omnii-1 is the largest multimodal genome language model ever built, capable of understanding and designing biology to advance new medicines, disease detection and biodefense From AI-generated DNA to a human patient Radical…
WEST LAFAYETTE — Researchers at Purdue University and the National Heart, Lung, and Blood Institute have uncovered an unexpected role for a human immune protein that could help scientists better understand how the body responds to infections, including HIV. The study,…
For the past two years, Dr. Jesse Bloom, Professor in Fred Hutch’s Basic Sciences and Public Health Sciences Divisions, and postdoctoral fellow Dr. Tyler Starr have engaged in a high-stakes race... The evolving landscape of sarbecovirus ACE2 binding For the past…
Researchers built a human blood-brain barrier model combined with antiviral testing, validated it with anti-HIV drugs, showed TBEV crosses an intact barrier to infect astrocytes, and identified a barrier-permeable antiviral candidate. Subject of Research: An in vitro human blood-brain barrier…
International Journal of Antimicrobial Agents publishes data showing that BV100 reaches concentrations in lung fluid and alveolar macrophages approximately 35-fold and over 300-fold higher, respectively, than in plasma, providing a strong pharmacological rationale for BV100 use in severe CRAB pneumonia Journal of…
The study built on the group’s previously published human primary cell-based BBB model. Barrier integrity in the current experiments was confirmed using transepithelial electrical resistance (TEER) measurements and FITC-dextran permeability assays, ensuring that observed drug movement reflected a functioning barrier…
Consistent with these observations, depleting BST-2 in interferon-stimulated macrophages had no impact on cell-to-cell virus transfer, the formation of MGCs, or virus production. The authors conclude that this route of macrophage infection escapes BST-2-mediated restriction independently of the Vpu…
A new review finds bacteriophage therapy shows promise against antibiotic-resistant livestock infections, but most evidence remains limited to laboratory and controlled animal studies. Subject of Research: Bacteriophage therapy as an alternative to antibiotics for bacterial infections in livestock News Source:…
What doesn’t kill a bacterium makes it stronger. An enzyme that bacteria use to fight off viruses works by targeting not just the virus, but also the bacterium itself. It sends the bacterium into a dormant state and makes it…
Virology as science: how viruses infect cells and replicate, virus structure and evolution, giant viruses, and bacteriophages and phage therapy.
An article joins this feed when it matches these terms. Each one is also a search of its own.