Researchers have developed an efficient algorithm that partitions the RNA branching parameter space to reveal all distinct optimal secondary structures a sequence can adopt. News Source: Gregory Coleman. (October 29, 2026). New Algorithm Maps Every Optimal RNA Fold Across Branching Parameters. Scienmag.
A new study finds that the Drosophila protein Rumpelstiltskin maintains the Homie insulator barrier and shapes Polycomb domain interactions in cis and trans.
Researchers at the University of Eastern Finland have identified a transporter protein with the potential to open new avenues for improving creatine delivery into the brain and for developing other therapies targeting the central nervous system. Novel transporter protein discovery…
A PLOS Pathogens study provides the first systematic characterization of defective viral genomes generated during PRRSV-2 infection, linking them to nsp2 deletion variants and showing broad antiviral activity. The research team, led by Hao Song and Tongqing An, analyzed publicly available…
“This is a novel folding and assembly corrector that could become a drug candidate,” commented Jeff Kelly of Scripps Research Institute in La Jolla, California. In the Dimer Groove. Ebselen (ball and stick) bound to SOD1 dimers at cysteine-111 residues at…
"The 3D genome structure provides the physical molecular basis of gene expression processes in cells," explains iCeMS systems biologist Yuichi Taniguchi, who led the research. To better visualize this structure, Taniguchi and colleagues developed Hi-CO, short for high-throughput chromosome conformation capture…
Researchers have unveiled a new RNA editing platform that coaxes a cell’s own editing enzyme into correcting RNA transcripts with efficiencies approaching 100 percent in cultured cells and 84 percent in living mice. The system, called MARRS, short for multivalent ADAR1-recruiting RNA…
A new Nature study shows that the Andes virus spike captures the PCDH1 receptor through a deep central pocket that most antibodies cannot reach. Scientists at Albert Einstein College of Medicine, working with collaborators at Institut Pasteur and LSU Health Shreveport,…
Non-homologous end joining (NHEJ) is the main repair pathway of double-strand DNA breaks in higher eukaryotes 1,2. Here we report reconstitution of the final steps of NHEJ and structures of DNA polymeraseâμ and ligase IV (LIG4) engaged in gap filling... Uncover the…
On the cellular highway, motor proteins called dyneins rule the road. Dyneins "walk" along structures called microtubules to deliver cellular cargo, such as signaling molecules and organelles, to different parts of a cell. Without dynein on the job, cells cannot…
Cryo-electron microscopy, cryo-electron tomography and electron microscopy of cells and molecules: new methods and the structures they reveal.
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