Researchers have introduced Sapling, a computational method that summarizes the many equally plausible tumor phylogenies inferred from bulk DNA sequencing into a small set of backbone trees. Subject of Research: Computational methods for inferring and summarizing tumor phylogenies from bulk…
Findings highlight the value of broad structural profiling when targeted testing leaves important questions unresolved The study evaluated the same proprietary Hi-C sequencing approach used in Aventa™ Lymphoma, Arima's clinical test for fusion and rearrangement detection in B- and T-cell…
Whole-exome sequencing of men from Kerala's high background radiation areas found no excess germline mutations compared with matched controls, despite roughly thirty-fold higher chronic radiation doses. Subject of Research: Germline variant detection by whole-exome sequencing in a human population chronically…
A pan-cancer analysis of about 11,000 TCGA samples maps the expression of all 29 SWI/SNF chromatin remodeling genes across 33 tumor types, finding distinct signatures in ten cancers and mostly downstream epigenetic effects of mutations. Subject of Research: Expression of SWI/SNF…
The results showed that SMYD2 was significantly upregulated in human chronic kidney disease samples, in cisplatin-treated mice, and in cisplatin-treated HK-2 cells. This convergence across human tissue, an animal model and cultured cells pointed to SMYD2 as a consistent feature of the…
According to the review, MALAT1 acts as a multifaceted oncogenic driver in AML, promoting the proliferation, survival, migration and chemoresistance of leukemia cells through several distinct molecular mechanisms. One of the best-characterized functions described is MALAT1’s activity as a competing endogenous…
Molecular dynamics simulations reveal that near-reactive docking geometries in KRAS G12C ligands rapidly collapse unless an explicit covalent bond stabilizes them. Article Title: Dynamic geometric constraints govern covalent feasibility in KRAS G12C ligands News Source: Bethany Barker. (October 29, 2026). Molecular dynamics show docking…
Researchers have developed Dolphyin, a combinatorial algorithm that infers 1-Dollo phylogenies from single-cell cancer sequencing data and proved that the linear version of the problem can be solved in polynomial time. Article Title: Dolphyin: a combinatorial algorithm for identifying 1-Dollo…
A study of TCGA and Brazilian cervical cancer cohorts found that two ERAP1 haplotypes were associated with significantly worse survival in the TCGA cohort.
Family trees of lung cancer cells, built using CRISPR-based lineage tracing, reveal how cancer evolves from its earliest stages to become aggressive and capable of spreading throughout the body. Centers, Labs, & Programs - Tracing a cancer’s family tree to its roots…
Cancer genomes and targeted treatment: tumour sequencing, driver mutations such as KRAS, EGFR and BRCA, and drugs matched to them.
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