Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a promising new strategy to make cancer-fighting immune cells stronger and potentially longer-lasting, a discovery that could help improve the effectiveness of immunotherapies that use a patient's own immune…
A previously unknown mechanism helps cancer cells selectively produce proteins that drive tumor growth - such as KRAS - in common cancers, according to new research from The University of Texas MD Anderson Cancer Center. The findings reveal that targeting a specific…
(L to R) Qianqian Li, PhD; Dana Farmer, PhD; first author Justin Williams, PhD; corresponding author Martine Roussel, PhD, all of St. Jude Department of Tumor Cell Biology, and Jake Friske, PhD, St. Jude Graduate School of Biomedical Sciences Pediatric brain…
Complexity of pancreatic cancer reproduced in the laboratory The team used machine learning to categorize the newly grown organoids based on their morphologies in defined groups for further systematic analyses. "We identified different phenotypes within the two subtypes epithelial and…
At the same time, antibody based therapies— despite their success in peripheral tumors— largely fail to access the brain parenchyma at therapeutically relevant levels. This disconnect has driven an urgent need for new BBB transport routes that are both selective…
A central finding concerns the malignant cells themselves. The team subdivided them into three distinct subclusters, each carrying its own unique transcriptional program. Pseudotime trajectory analysis suggested a developmental hierarchy among these malignant populations, a structure supported by the dynamic…
Researchers have introduced Sapling, a computational method that summarizes the many equally plausible tumor phylogenies inferred from bulk DNA sequencing into a small set of backbone trees. Subject of Research: Computational methods for inferring and summarizing tumor phylogenies from bulk…
A-gyo and UN-gyo achieved 100% complete tumor regression in animal models of human colorectal, ovarian, and pancreatic cancer, with no observable systemic toxicity. A remarkable study published in Nature Biomedical Engineering reports 100% complete tumor regression in mouse models of human colorectal,…
A newly published consensus standard defines unified workflows, validation criteria and drug testing protocols for breast cancer organoids grown from surgical tissues, biopsies, body fluids and circulating tumor cells. Subject of Research: A consensus standard for establishing, validating and applying…
To probe this relationship, the team used a syngeneic triple-negative breast cancer mouse model of liver metastasis. In this model, they investigated the immunoregulatory role of neutrophils in modulating NK cell activity, focusing on how neutrophils recovered from breast cancer…
How cancers start, grow and spread: tumour cells and their microenvironment, metastasis, cancer stem cells, cancer metabolism, oncogenes and tumour suppressors.
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