A central finding concerns the malignant cells themselves. The team subdivided them into three distinct subclusters, each carrying its own unique transcriptional program. Pseudotime trajectory analysis suggested a developmental hierarchy among these malignant populations, a structure supported by the dynamic…
This retrospective study evaluated the impact of a pre-emptive rituximab (RTX) strategy for EpsteinâBarr virus (EBV) reactivation on immune recovery and outcomes of 219 high-risk recipients undergoing allogeneic stem cell transplantation (allo-SCT)... Thank you for visiting nature.com. You are…
Perforin increases endosomal-mitochondrial contact sites in tumor cells. Left is without perforin; right is with perforin Newswise — ANN ARBOR, Michigan – For decades, scientists have known that a protein made by T cells and natural killer (NK) cells in the immune…
Organoid and clinical single-cell data link a DHX58-positive, CD62L-positive stem-like T-cell state to immune checkpoint blockade responsiveness in gastric cancer. Article Title: DHX58/LGP2 and L-selectin/CD62L mark a stem-like T-cell state associated with immune checkpoint blockade responsiveness in gastric cancer News Source:…
A novel antibody therapy has strengthened the immune system’s ability to fight cancer in mice by targeting immune-suppressing cells more precisely than previous approaches, according to new research. The treatment, developed by Baomei Wang and colleagues at Genentech, targeted regulatory…
A new review maps five variables that determine whether necroptosis primes antitumor immunity or fuels tumor growth, positioning radiotherapy as a key setting for exploiting the pathway. News Source: Nathaniel Bowman. (October 29, 2026). Necroptosis emerges as a decisive switch between tumor…
A new study combining a literature review, expert interviews and a two-round Delphi consensus proposes a contemporary, interdisciplinary definition of immunochemistry.
A new review outlines how lipid-based nanomedicines could deliver pathway-specific siRNA to treat hepatocellular carcinoma, highlighting delivery design, preclinical candidates and clinical constraints.
Professor of Immunology at the University of Manchester Author and Professor of Immunology at Imperial College London Professor of Inflammation Biology at the University of Southampton In Our Time is a BBC Studios production A world-class seminar every week. Spanning…
A four-patient PET study found that the activated T cell tracer [18F]F-AraG is best quantified with a two-tissue irreversible model and a tumor-to-plasma ratio, with no treatment-induced kinetic changes during STING agonist and anti-PD-1 immunotherapy. Subject of Research: Pharmacokinetic modeling…
Turning the immune system on cancer: checkpoint inhibitors, cancer vaccines and tumour immunology research.
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