A time-resolved proteomic study in mice shows that loss of the desmosomal protein plakophilin-2 triggers right-ventricle-led molecular remodeling, with early mitochondrial alterations that honokiol treatment broadly attenuated.
Combinatorial biosynthesis in Magnaporthe grisea shows that cytochalasan P450 enzymes tolerate macrocycle size differences but are restricted by the stereochemistry of methyl groups around the backbone.
A new review examines how pigments from fungi, bacteria and microalgae could replace synthetic food dyes, and what obstacles remain.
Preclinical study results suggest how the heart can keep itself well-fueled even under times of stress, by burning glucose in the cell cytosol while burning lactate in the mitochondria. The post How the Heart Stays Strong with MCT1-Dependent Mitochondrial Lactate…
The results are published in Nature. "This appears to be a critical backup system for heart function," says Gregory Ducker, PhD, assistant professor of biochemistry at University of Utah Health and senior author on a paper describing the results. "In…
The results are published in Nature. “This appears to be a critical backup system for heart function,” says Gregory Ducker, PhD, assistant professor of biochemistry at University of Utah Health and senior author on a paper describing the results. “In…
The prescription drug tadalafil changed the growth and development of mouse muscle precursor cells in a laboratory study, giving researchers a possible lead for studying muscle repair. Cells exposed to tadalafil for up to seven days were more numerous and…
A multi-omics study links linalool treatment in cigar tobacco fermentation to a more modular microbial network and phase-dependent metabolic changes, contrasting with the centralized structure and off-flavor precursor buildup associated with sodium dehydroacetate. Alongside these metabolic shifts, the linalool condition…
This paper reviews amino acid fragmentation under hydrothermal and pyrolytic conditions, highlighting deamination and decarboxylation as key reactions where structural differences dictate degradation pathways, and explores production methods like microbial fermentation and catalytic synthesis from nitrogen-rich biomass. Degradation Pathways of…
A study of goat embryos identifies CDK1 as a hub gene whose moderate expression promotes muscle satellite cell proliferation, while excessive levels trigger cell cycle arrest. Researchers studying goat embryogenesis have identified the cell-cycle gene CDK1 as a hub regulator of skeletal…
The chemistry of life: metabolism and metabolic pathways, enzymes at work, lipids, sugars, amino acids and the metabolites inside cells.
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