A systematic analysis of hundreds of WGBS datasets finds that apparent mitochondrial DNA methylation is driven mainly by technical artifacts, particularly missing DNA fragmentation and incomplete bisulfite conversion. Article Title: Apparent methylation of mitochondrial DNA in WGBS is dominated by…
A study in mice and liver cells finds that the USP18–STAT2 axis, activated by interferon priming, protects hepatocytes from proteasome-inhibitor-induced proteotoxic stress. Liver Survival Protein USP18 Protects Cells From Proteotoxic Stress Subject of Research: How the USP18–STAT2 interferon signalling axis protects liver cells…
The new findings suggest that visible variation across mainland India does not correspond to clear genetic divisions. Sri Lankan cobras, however, show a distinct evolutionary pattern, even though the researchers conclude that the available genetic evidence does not establish them…
In amyotrophic lateral sclerosis (ALS), motor neurons in the spinal cord and central nervous system die off for unknown reasons, causing creeping paralysis and, eventually, death. Mutations in the... In amyotrophic lateral sclerosis (ALS), motor neurons in the spinal cord…
A new review maps how mitophagy and the cGAS–STING pathway may jointly regulate post-stroke neuroinflammation through leaking mitochondrial DNA, based on animal and cell-model evidence. Subject of Research: The interplay between mitophagy and the cGAS–STING pathway in neuroinflammation…
A new gecko species, Gekko luanchuanensis, has been described from the Qinling Mountains in Henan Province, China, based on morphology and mitochondrial DNA.
Deleting the lipid droplet kinase gene in Trypanosoma cruzi reduced lipid droplet accumulation, increased resistance to hydrogen peroxide, and sharply lowered infectivity in fibroblasts without affecting parasite growth or benznidazole susceptibility. Researchers have carried out the first functional characterization of…
A new review maps how intercellular mitochondrial transfer and transplantation could treat central nervous system disorders, while flagging dye-labeling artifacts and scarce functional validation as key obstacles. The authors focus on what triggers mitochondrial transfer, the direction it takes, the…
Trace Thome is in the Cardiovascular Institute and the Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104, USA. Hui, S. et al. Cell Metab. 32, 676–688 (2020). Murashige, D. et al. Science 370, 364–368 (2020). Bornstein, M. R., Tian, R. & Arany, Z. Cell Metab.
The disc’s nucleus pulposus is an unforgiving niche. Its cells live under chronic hypoxia, limited nutrient supply, acidic stress and constant mechanical loading. According to the review, metabolites accumulating in this environment are not merely fuel for energy production; they…
Mitochondria and how cells make and use energy: mitochondrial biology, mitochondrial DNA and disease, and cellular respiration.
An article joins this feed when it matches these terms. Each one is also a search of its own.