In the Drosophila ovary, Notch activation upregulates the E2 enzyme Ubc10, which teams with the E3 ligases Ari-1 and Cul3 to degrade the Hedgehog effector Ci and specify cap cells that form the germline stem cell niche.
A narrative review links iron-dependent ferroptosis to tumor progression and therapy response in digestive system cancers, while flagging major barriers to clinical translation. News Source: Nathaniel Bowman. (October 29, 2026). Ferroptosis emerges as a central vulnerability in digestive system cancers. Scienmag.
A new review frames the cGAS-STING DNA-sensing pathway as a self-reinforcing inflammatory amplifier that links cellular damage to whole-joint remodeling in osteoarthritis. Among the DNA species that can trigger this cascade, the review identifies cytosolic mitochondrial DNA as currently having…
For decades, scientists have been able to look at individual moments in the development of an embryo: a snapshot of a developing brain, a picture of how the heart takes shape, or a glimpse of cells beginning to form the…
"The 3D genome structure provides the physical molecular basis of gene expression processes in cells," explains iCeMS systems biologist Yuichi Taniguchi, who led the research. To better visualize this structure, Taniguchi and colleagues developed Hi-CO, short for high-throughput chromosome conformation capture…
A new Nature Chemical Biology study identifies the NAD+ catabolite ADP-ribose as an inducer of neuronal ferroptosis through inhibition of the nucleoside transporter ENT2.
A new review argues that disrupted lipid handling in astrocytes may amplify motor neuron injury and disease progression in ALS.
A new lineage-tracing study in the annelid Tubifex tubifex shows that each small micromere of the early embryo follows a fixed fate and that their left-right positions at the 22-cell stage already predict which half of the juvenile body they…
A reducing reagent-resistant dimer of transferrin receptor 1 emerges during lipid peroxidation and can be detected in tissues and blood-borne extracellular vesicles as a specific marker of ferroptosis in mice and humans.
Scientists have identified a new post-translational mechanism that controls levels of VPS35, a core component of the retromer complex best known for its role in Parkinson’s disease. The work was published on 15 October 2026 as an open-access research article. The team also…
Cell biology: organelles, membranes, the cytoskeleton, cell division, cell signalling, autophagy and the ways cells die.
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