Researchers have developed an efficient algorithm that partitions the RNA branching parameter space to reveal all distinct optimal secondary structures a sequence can adopt. News Source: Gregory Coleman. (October 29, 2026). New Algorithm Maps Every Optimal RNA Fold Across Branching Parameters. Scienmag.
A new study finds that the Drosophila protein Rumpelstiltskin maintains the Homie insulator barrier and shapes Polycomb domain interactions in cis and trans.
Researchers in Japan engineered an ancestral nucleoside diphosphate kinase variant with a restricted amino acid repertoire and found that it retained its fold and converted two ADP molecules into ATP and AMP.
Researchers at the University of Eastern Finland have identified a transporter protein with the potential to open new avenues for improving creatine delivery into the brain and for developing other therapies targeting the central nervous system. Novel transporter protein discovery…
A PLOS Pathogens study provides the first systematic characterization of defective viral genomes generated during PRRSV-2 infection, linking them to nsp2 deletion variants and showing broad antiviral activity. The research team, led by Hao Song and Tongqing An, analyzed publicly available…
Study explored how restricting the amino acid diversity in ancestral enzymes can uncover alternative catalytic functions, including ATP formation from ADP Overall, the study shows that restricting amino acid diversity can reveal catalytic capabilities beyond a protein’s conventional function. By…
This is why understanding the interactions surrounding G4 is so important. Biochemical assays give us more information about the intricacies of these interactions. These assays assess the way DNA and proteins interact, which occurs in processes such as DNA replication, transcription,…
“This is a novel folding and assembly corrector that could become a drug candidate,” commented Jeff Kelly of Scripps Research Institute in La Jolla, California. In the Dimer Groove. Ebselen (ball and stick) bound to SOD1 dimers at cysteine-111 residues at…
Chia-Hsueh Lee, PhD, and Yaxin Dai, PhD, St. Jude Department of Structural Biology obtained ten structures of the human urate transporter URAT1 to uncover the transporter’s mechanism of action and provide insight into future drug discovery efforts to treat gout and…
A new immunoisolation method called mammalian MemPrep delivers a high-confidence lipid and protein inventory of the endoplasmic reticulum in HEK293T cells, showing that ER tubules and the rest of the ER share nearly identical lipid compositions.
Protein structures and molecular machines: protein folding and misfolding, cryo-EM and crystal structures of biomolecules and how proteins work.
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